微生物群在疫苗免疫反应调节中的作用。

Ciabattini Annalisa, Olivieri Raffaela, Lazzeri Elisa, Medaglini Donata

Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Siena, Italy.

Front Microbiol. 2019 Jul 3;10:1305. doi: 10.3389/fmicb.2019.01305. eCollection 2019.

The human immune system and the microbiota co-evolve, and their balanced relationship is based on crosstalk between the two systems through the course of life. This tight association and the overall composition and richness of the microbiota play an important role in the modulation of host immunity and may impact the immune response to vaccination. The availability of innovative technologies, such as next-generation sequencing (NGS) and correlated bioinformatics tools, allows a deeper investigation of the crosstalk between the microbiota and human immune responses. This review discusses the current knowledge on the influence of the microbiota on the immune response to vaccination and novel tools to deeply analyze the impact of the microbiome on vaccine responses.

人类免疫系统与微生物群共同进化，它们之间的平衡关系基于这两个系统在生命过程中的相互作用。这种紧密联系以及微生物群的整体组成和丰富度在调节宿主免疫方面发挥着重要作用，并且可能影响对疫苗接种的免疫反应。创新技术的出现，如下一代测序（NGS）和相关的生物信息学工具，使得对微生物群与人类免疫反应之间的相互作用有更深入的研究成为可能。本综述讨论了关于微生物群对疫苗接种免疫反应影响的现有知识，以及深入分析微生物组对疫苗反应影响的新工具。