接受抗癫痫药物治疗患者白细胞中的锌浓度。
Zinc concentrations in leucocytes of patients receiving antiepileptic drugs.
作者信息
Yuen W C, Whiteoak R, Thompson R P
机构信息
Department of Neurology, Rayne Institute, St Thomas's Hospital, London.
出版信息
J Clin Pathol. 1988 May;41(5):553-5. doi: 10.1136/jcp.41.5.553.
Abstract
To determine whether some of the side effects of antiepileptic drugs could be due to zinc depletion within tissues, zinc concentrations in the polymorphonuclear leucocytes in 26 epileptic patients receiving valproate or carbamazepine and 14 controls were assessed. There was no difference in zinc concentration in leucocytes among the three groups and no evidence of zinc depletion. Valproate and carbamazepine may affect the intracellular distribution of zinc.
摘要
为了确定抗癫痫药物的某些副作用是否可能归因于组织内锌缺乏，我们评估了26例接受丙戊酸盐或卡马西平治疗的癫痫患者以及14名对照者的多形核白细胞中的锌浓度。三组白细胞中的锌浓度没有差异，也没有锌缺乏的证据。丙戊酸盐和卡马西平可能会影响锌的细胞内分布。
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