Sözüer D T, Barutçu U B, Karakoç Y, Yalçin E, Onen S
Department of Pediatric Neurology, Cerrahpaşa Medical Faculty, Istanbul, Turkey.
J Basic Clin Physiol Pharmacol. 1995;6(3-4):265-9. doi: 10.1515/jbcpp.1995.6.3-4.265.
The results of previous studies that examined serum trace metal status of epileptic patients receiving antiepileptic drug (AED) therapy were variable. We measured serum zinc (Zn) and copper (Cu) levels in 52 epileptic children who were treated with either carbamazepine (CBZ) or valproic acid (VPA) or with a combination of CBZ and VPA. Serum Zn levels were significantly lower in the epileptics than in the two control groups which consisted of 7 untreated epileptics and 12 normal children (p < 0.05). Combination therapy and monotherapy with CBZ increased serum Cu levels (p < 0.05). No significant alteration in serum Cu levels was observed with VPA monotherapy. Serum Zn and serum Cu concentrations of the untreated epileptics were not significantly different from those of normal controls. Our results indicate that serum trace metal homeostasis may be affected by AED therapy, but not by the convulsive disorder itself.
以往研究抗癫痫药物（AED）治疗的癫痫患者血清微量元素状况的结果各不相同。我们检测了52例接受卡马西平（CBZ）、丙戊酸（VPA）或CBZ与VPA联合治疗的癫痫儿童的血清锌（Zn）和铜（Cu）水平。癫痫患者的血清Zn水平显著低于由7例未经治疗的癫痫患者和12例正常儿童组成的两个对照组（p<0.05）。CBZ联合治疗和单药治疗可提高血清Cu水平（p<0.05）。VPA单药治疗未观察到血清Cu水平有显著变化。未经治疗的癫痫患者的血清Zn和血清Cu浓度与正常对照组无显著差异。我们的结果表明，血清微量元素稳态可能受AED治疗的影响，但不受惊厥性疾病本身的影响。
