Azari Iman, Ghafouri-Fard Soudeh, Omrani Mir Davood, Arsang-Jang Shahram, Kordi Tamandani Dor Mohammad, Saroone Rigi Mehrnaz, Rafiee Sara, Pouresmaeili Farkhondeh, Taheri Mohammad
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rep Biochem Mol Biol. 2019 Apr;8(1):25-31.
Intrauterine growth restriction (IUGR), a pathologic diminution of the rate of fetal growth, has been associated with alterations in expression of several genes. However, the role of long non-coding RNAs (lncRNAs) in its pathogenesis has not been studied.
In this study we evaluated the expression of four lncRNAs namely, nuclear paraspeckle assembly transcript (), taurine up-regulated 1 (), p21-associated ncRNA DNA damage-activated (), and metastasis-associated lung adenocarcinoma transcript-1 () in placenta samples obtained from IUGR and normal pregnancies to determine their possible contributions in the pathogenesis of IUGR.
We found no significant differences in expression levels between cases and controls. We also found no correlation between expression and clinical data of study participants; however, we found significant correlations between expression levels of all the assessed lncRNAs in both cases and controls.
These results imply the existence of a possible shared regulatory mechanism for the expression of these transcripts in placenta. Future studies are needed to perform such evaluations in larger sample sizes or in animal models in earlier stages of pregnancy.
胎儿生长受限（IUGR）是胎儿生长速率的病理性降低，与多个基因表达的改变有关。然而，长链非编码RNA（lncRNA）在其发病机制中的作用尚未得到研究。
在本研究中，我们评估了四种lncRNA，即核旁斑组装转录本（）、牛磺酸上调基因1（）、p21相关非编码RNA DNA损伤激活（）和转移相关肺腺癌转录本-1（）在取自IUGR妊娠和正常妊娠的胎盘样本中的表达，以确定它们在IUGR发病机制中的可能作用。
我们发现病例组和对照组之间的表达水平无显著差异。我们还发现表达与研究参与者的临床数据之间无相关性；然而，我们发现病例组和对照组中所有评估的lncRNA的表达水平之间存在显著相关性。
这些结果表明在胎盘中这些转录本的表达可能存在共同的调控机制。未来需要进行更大样本量的评估或在妊娠早期的动物模型中进行此类评估。
