一种突变型伯基特淋巴瘤细胞系中的增强子因子缺陷。
An enhancer factor defect in a mutant Burkitt lymphoma cell line.
作者信息
Koch W, Candeias S, Guardiola J, Accolla R, Benoist C, Mathis D
机构信息
Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique, Unité 184, Strasbourg.
出版信息
J Exp Med. 1988 Jun 1;167(6):1781-90. doi: 10.1084/jem.167.6.1781.
Abstract
RJ 2.2.5 is an immunoselected mutant of the Burkitt lymphoma line Raji. It fails to display MHC class II antigens at the cell surface due to a transcriptional defect. We have identified the function of a regulatory factor that is defective in RJ 2.2.5 cells; this factor is absolutely required for the activity of an MHC class II gene enhancer.
摘要
RJ 2.2.5是伯基特淋巴瘤细胞系Raji的一个经免疫筛选的突变体。由于转录缺陷，它无法在细胞表面展示MHC II类抗原。我们已经确定了一种在RJ 2.2.5细胞中存在缺陷的调节因子的功能；该因子对于MHC II类基因增强子的活性是绝对必需的。
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