Matsui Shusuke, Hosho Kensuke, Minato Haruka, Uchihashi Takayuki, Suzuki Daisuke
Graduate School of Textile Science & Technology, Shinshu University, 3-15-1 Tokida, Ueda, Nagano 386-8567, Japan.
Department of Physics and Structural Biology Research Center, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8602, Japan.
Chem Commun (Camb). 2019 Sep 4;55(68):10064-10067. doi: 10.1039/c9cc05116c. Epub 2019 Jul 23.
The moment of protein uptake into hydrogel microspheres (microgels) was directly monitored at the nanoscale by high-speed atomic force microscopy. The dynamic morphological changes in the microgels during protein uptake are largely different depending on the type of protein, and the properties and structure of the microgels, which would affect the colloidal stability of protein-microgel hybrids both in vitro and in vivo.
通过高速原子力显微镜在纳米尺度直接监测蛋白质进入水凝胶微球（微凝胶）的时刻。蛋白质摄取过程中微凝胶的动态形态变化因蛋白质类型、微凝胶的性质和结构而有很大差异，这会影响蛋白质 - 微凝胶杂化物在体外和体内的胶体稳定性。
