Team Memory, Oscillations and Brain States (MOBs), Brain Plasticity Unit, CNRS, ESPCI Paris, PSL University, Paris, France.
Hippocampus. 2020 Jan;30(1):19-27. doi: 10.1002/hipo.23143. Epub 2019 Jul 23.
Sleep is important for memory consolidation, and an abundant literature suggests that reactivation in the hippocampus during sleep is instrumental to this process. Yet, the current interpretation of activity during sharp-waves ripples (SWRs), as replay of wake experiences, relies on hypotheses that, while widely accepted, have only recently begun to be tested directly. Moreover, this theory has been mainly studied in the context of pure spatial learning, and it is still not clear how emotional valence can fit into this conceptual framework when considering reward- or punishment-based learning. In this review, we will present recent experimental arguments validating the interpretation of sleep replay as reactivation of awake experiences and examine the evidence showing that the emotional valence is also replayed during sleep in a coordinated fashion with hippocampal SWRs. Finally, we will detail recent experiments showing that brain-computer interfaces can be used to modify the emotional valence associated with sleep replay.
睡眠对于记忆巩固很重要，大量文献表明，睡眠期间海马体的重新激活对这一过程至关重要。然而，目前关于尖波涟漪（SWR）期间活动的解释，即清醒体验的重演，依赖于虽然被广泛接受但最近才开始直接测试的假设。此外，该理论主要在纯空间学习的背景下进行研究，当考虑基于奖励或惩罚的学习时，情绪效价如何适应这一概念框架仍不清楚。在这篇综述中，我们将介绍最近的实验论据，这些论据证实了睡眠重放作为清醒体验的重新激活的解释，并研究了表明情绪效价也在睡眠中与海马体 SWR 协调重放的证据。最后，我们将详细介绍最近的实验，这些实验表明脑机接口可用于修改与睡眠重放相关的情绪效价。
