School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, UK.
Institut für Biologie/Mikrobiologie, Humboldt-Universität zu Berlin, Berlin, Germany.
Microbiology (Reading). 2019 Sep;165(9):929-952. doi: 10.1099/mic.0.000817.
is a Gram-positive, filamentous actinomycete with a complex developmental life cycle. Genomic analysis revealed that encodes a large number of two-component systems (TCSs): these consist of a membrane-bound sensor kinase (SK) and a cognate response regulator (RR). These proteins act together to detect and respond to diverse extracellular signals. Some of these systems have been shown to regulate antimicrobial biosynthesis in species, making them very attractive to researchers. The ability of to sporulate in both liquid and solid cultures has made it an increasingly popular model organism in which to study these industrially and medically important bacteria. Bioinformatic analysis identified 58 TCS operons in with an additional 27 orphan SK and 18 orphan RR genes. A broader approach identified 15 of the 58 encoded TCSs to be highly conserved in 93 species for which high-quality and complete genome sequences are available. This review attempts to unify the current work on TCS in the streptomycetes, with an emphasis on .
是一种革兰氏阳性、丝状放线菌，具有复杂的发育生命周期。基因组分析表明， 编码大量的双组分系统（TCS）：这些系统由膜结合的传感器激酶（SK）和同源反应调节剂（RR）组成。这些蛋白质共同作用，以检测和响应各种细胞外信号。已经证明其中一些系统调节 种属中的抗生素生物合成，这使得它们成为研究这些在工业和医学上重要的细菌的非常有吸引力的对象。 的在液体和固体培养物中能够形成孢子的能力使其成为研究这些工业和医学上重要的细菌的越来越受欢迎的模式生物。生物信息学分析在 中鉴定出 58 个 TCS 操纵子，另有 27 个孤立的 SK 和 18 个孤立的 RR 基因。更广泛的方法确定了 15 个编码 TCS 在 93 种高质量和完整基因组序列可用的 物种中高度保守。这篇综述试图将链霉菌中的 TCS 目前的工作统一起来，重点是 。
