Hoyt Brian S, Aaron Denise M, Yan Shaofeng, Linos Konstantinos D
Department of Surgery, Section of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Division of Dermatopathology, Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Am J Dermatopathol. 2019 Aug;41(8):e84-e86. doi: 10.1097/DAD.0000000000001374.
Crospovidone, a polymer of poly N-vinyl-2-pyrrolidone, is an inert insoluble disintegrant found in pharmaceutical tablets. This material has been encountered in the lungs of intravenous drug users and embolized with other components such as talc and microcrystalline cellulose. More recently, crospovidone has also been described in the gastrointestinal tract. We present 2 cases of cutaneous crospovidone deposition resulting from subcutaneous injection of crushed tablets, commonly known as "skin popping." Clinical presentation includes painful, inflamed papules, nodules, or ulcers with overlying eschar. Crospovidone has a distinct and reproducible histochemical staining profile. Histologic recognition of this material is important because it can guide clinicians in their diagnosis and management decisions.
交联聚维酮是聚N-乙烯基-2-吡咯烷酮的聚合物，是一种存在于药片中的惰性不溶性崩解剂。这种物质在静脉吸毒者的肺部被发现，并与滑石粉和微晶纤维素等其他成分一起形成栓子。最近，交联聚维酮也在胃肠道中被发现。我们报告了2例因皮下注射碾碎的药片（俗称“皮肤注射”）导致皮肤交联聚维酮沉积的病例。临床表现包括疼痛、发炎的丘疹、结节或伴有焦痂的溃疡。交联聚维酮具有独特且可重复的组织化学染色特征。对这种物质的组织学识别很重要，因为它可以指导临床医生进行诊断和管理决策。
