Children's National Medical Center, Department of Pathology, Washington, District of Columbia.
Office of the Chief Medical Examiner, Baltimore, Maryland.
Pediatr Dev Pathol. 2020 Sep-Oct;23(5):404-407. doi: 10.1177/1093526620935738. Epub 2020 Jul 9.
Intravenous injection of medications intended for oral use can lead to pulmonary hypertension and death. Pathologic findings in the lung include embolization of foreign material, with the specific identification of excipients accomplished through special stains. Risk factors for this type of drug abuse include indwelling venous access and chronic medical problems. These risk factors, especially in adolescent and young adult patients, should prompt intravenous drug use as a possibility of lung disease/lesions. We describe 2 patients from a pediatric hospital with pulmonary pathology indicative of intravenous drug use, identified in autopsy and surgical pathology cases. Drug abuse was not clinically suspected in either patient until the time of pathologic exam, emphasizing a need for the pathologist to be able to recognize the associated histologic changes.
静脉注射用于口服的药物会导致肺动脉高压和死亡。肺部的病理发现包括异物栓塞，通过特殊染色可以确定赋形剂的具体鉴定。这种药物滥用的危险因素包括留置静脉通路和慢性医疗问题。这些危险因素，特别是在青少年和年轻成年患者中，应提示静脉内药物使用作为肺部疾病/病变的可能性。我们描述了来自儿童医院的 2 例患者，他们的肺部病理学表现表明存在静脉内药物使用，这在尸检和外科病理学病例中得到了证实。在病理检查之前，这两名患者的临床均未怀疑有药物滥用，这强调了病理学家需要能够识别相关的组织学变化。
