Department of Neurology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Department of Internal Medicine, Jinzhou Medical University, Jinzhou, Liaoning 121001, China.
Chin Med J (Engl). 2019 Aug 20;132(16):1965-1973. doi: 10.1097/CM9.0000000000000358.
Recent studies have shown the important influence of various micro factors on the general biological activity and function of endothelial cells (ECs). Vascular endothelial growth factor (VEGF) and angiogenin (ANG) are classic micro factors that promote proliferation, differentiation, and migration of ECs. The underlying pathophysiological mechanisms and related pathways of these micro factors remain the focus of current research.
An extensive search was undertaken in the PubMed database by using keywords including "micro factors" and "endothelial cell." This search covered relevant research articles published between January 1, 2007 and December 31, 2018.
Original articles, reviews, and other articles were searched and reviewed for content on micro factors of ECs.
VEGF and ANG have critical functions in the occurrence, development, and status of the physiological pathology of ECs. Other EC-associated micro factors include interleukin 10, tumor protein P53, nuclear factor kappa B subunit, interleukin 6, and tumor necrosis factor. The results of Gene Ontology analysis revealed that variations were mainly enriched in positive regulation of transcription by the RNA polymerase II promoter, cellular response to lipopolysaccharides, negative regulation of apoptotic processes, external side of the plasma membrane, cytoplasm, extracellular regions, cytokine activity, growth factor activity, and identical protein binding. The results of the Kyoto Encyclopedia of Genes and Genomes analysis revealed that micro factors were predominantly enriched in inflammatory diseases.
In summary, the main mediators, factors, or genes associated with ECs include VEGF and ANG. The effect of micro factors on ECs is complex and multifaceted. This review summarizes the correlation between ECs and several micro factors.
最近的研究表明，各种微观因素对内皮细胞（EC）的一般生物学活性和功能有重要影响。血管内皮生长因子（VEGF）和血管生成素（ANG）是促进 EC 增殖、分化和迁移的经典微观因素。这些微观因素的潜在病理生理机制和相关途径仍然是当前研究的重点。
通过使用“微因子”和“内皮细胞”等关键词，在 PubMed 数据库中进行了广泛的搜索。该搜索涵盖了 2007 年 1 月 1 日至 2018 年 12 月 31 日期间发表的相关研究文章。
搜索并回顾了有关 EC 微观因素的原始文章、综述和其他文章。
VEGF 和 ANG 在 EC 的生理病理发生、发展和状态中具有关键作用。其他与 EC 相关的微观因素包括白细胞介素 10、肿瘤蛋白 P53、核因子 kappa B 亚基、白细胞介素 6 和肿瘤坏死因子。基因本体论分析的结果表明，变化主要富集在 RNA 聚合酶 II 启动子的转录正调控、细胞对脂多糖的反应、凋亡过程的负调控、质膜外、细胞质、细胞外区、细胞因子活性、生长因子活性和相同蛋白结合。京都基因与基因组百科全书分析的结果表明，微观因素主要富集在炎症性疾病中。
综上所述，与 EC 相关的主要介质、因素或基因包括 VEGF 和 ANG。微观因素对 EC 的影响是复杂和多方面的。本综述总结了 EC 与几种微观因素的相关性。
