School of Psychology, University of Queensland, Brisbane, Australia.
School of Psychology, University of Queensland, Brisbane, Australia.
Neurosci Biobehav Rev. 2019 Sep;104:255-267. doi: 10.1016/j.neubiorev.2019.07.011. Epub 2019 Jul 20.
Social perceptual impairment is a common presenting feature of Parkinson's disease (PD) that has the potential to contribute considerably to disease burden. The current study reports a meta-analytic integration of 79 studies which shows that, relative to controls, PD is associated with a moderate emotion recognition deficit (g = -0.57, K = 73), and that this deficit is robust and almost identical across facial and prosodic modalities. However, the magnitude of this impairment does appear to vary as a function of task and emotion type, with deficits generally greatest for identification tasks (g = -0.65, K = 54), and for negative relative to other basic emotions. With respect to clinical variables, dopaminergic medication, deep brain stimulation, and a predominant left side onset of motor symptoms are each associated with greater social perceptual difficulties. However, the magnitude of social perceptual impairment seen for the four atypical parkinsonian conditions is broadly comparable to that associated with PD. The theoretical and practical implications of these findings are discussed.
社会感知障碍是帕金森病（PD）的常见表现特征，有可能对疾病负担产生重大影响。本研究对 79 项研究进行了荟萃分析，结果表明，与对照组相比，PD 与中度情绪识别缺陷相关（g=-0.57，K=73），并且这种缺陷在面部和韵律模态中都是稳健且几乎相同的。然而，这种损伤的程度似乎确实会随着任务和情绪类型的变化而变化，识别任务的缺陷通常最大（g=-0.65，K=54），并且相对于其他基本情绪，负面情绪的缺陷更大。关于临床变量，多巴胺能药物、深部脑刺激和运动症状主要左侧发作都与更大的社会感知困难相关。然而，四种非典型帕金森病的社会感知障碍的严重程度与 PD 相关的严重程度大致相当。讨论了这些发现的理论和实际意义。
