Goldhirsch A, Berger E, Müller O, Maibach R, Misteli S, Buser K, Roesler H, Brunner K
Ludwig Institute for Cancer Research, Bern Branch, Inselspital, Switzerland.
Oncology. 1988;45(4):281-6. doi: 10.1159/000226623.
In an effort to correlate the serum values of potential markers, including CA-125, galactosyltransferase, and total sialic acid, with residual tumor mass after initial surgery, 43 patients with FIGO stage IIb and c, III and IV ovarian cancer were studied. The sensitivity of galactosyltransferase and sialic acid levels was sufficient to correlate their serum values with the corresponding residual tumor mass. Furthermore, 28 patients were histopathologically evaluated for their response to chemotherapy. Determination of these tumor markers did not permit discrimination between small residual disease (less than or equal to 1 cm) and a state of 'no evidence of disease'. Conversely, progression of disease has been associated with a sensitive increase in the level of all three markers. CA-125 has been found to be the most useful of the three for distinguishing between responders and nonresponders.
为了将包括CA - 125、半乳糖基转移酶和总唾液酸在内的潜在标志物的血清值与初次手术后的残余肿瘤质量相关联，对43例FIGO分期为IIb和c、III和IV期的卵巢癌患者进行了研究。半乳糖基转移酶和唾液酸水平的敏感性足以将其血清值与相应的残余肿瘤质量相关联。此外，对28例患者的化疗反应进行了组织病理学评估。这些肿瘤标志物的测定无法区分小的残余病灶（小于或等于1厘米）和“无疾病证据”状态。相反，疾病进展与所有三种标志物水平的敏感升高相关。已发现CA - 125是这三种标志物中区分反应者和无反应者最有用的一种。
