National Cancer Institute, Building 37 Room 4118, 9000 Rockville Pike, Bethesda, MD 20892-4263, United States.
National Cancer Institute, Building 37 Room 4118, 9000 Rockville Pike, Bethesda, MD 20892-4263, United States.
Curr Opin Virol. 2019 Dec;39:8-15. doi: 10.1016/j.coviro.2019.06.009. Epub 2019 Jul 20.
In 2014, the International Agency for Research on Cancer judged Merkel cell polyomavirus (MCPyV) to be a probable human carcinogen. BK polyomavirus (BKPyV, a distant cousin of MCPyV) was ruled a possible carcinogen. In this review, we argue that it has recently become reasonable to view both of these viruses as known human carcinogens. In particular, several complementary lines of evidence support a causal role for BKPyV in the development of bladder carcinomas affecting organ transplant patients. The expansion of inexpensive deep sequencing has opened new approaches to investigating the important question of whether BKPyV causes urinary tract cancers in the general population.
2014 年，国际癌症研究机构（IARC）判定 Merkel 细胞多瘤病毒（MCPyV）为可能的人类致癌病毒。BK 多瘤病毒（BKPyV，与 MCPyV 关系较远的一种病毒）则被归类为可能的致癌病毒。在本篇综述中，我们认为，现在将这两种病毒均视为已知的人类致癌病毒是合理的。具体而言，有几项互补的证据支持 BKPyV 在引起影响器官移植患者的膀胱癌的发展中起因果作用。廉价的深度测序技术的扩展为研究 BKPyV 是否会引起普通人群的泌尿道癌症这一重要问题提供了新的方法。
