Geriatric Clinic & Services, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, 560029, India.
Department of Neuroimaging and interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, 560029, India.
Asian J Psychiatr. 2019 Aug;44:99-105. doi: 10.1016/j.ajp.2019.07.001. Epub 2019 Jul 12.
F-FDG-PET is a potential sensitive biomarker indicating neuronal damage. F-FDG-PET has proven to be useful in subtyping dementia. Utility of simultaneous F-FDG-PET and MRI-brain was investigated in the evaluation of dementia in this facility.
All case notes of patients who underwent 18 F-FDG-PET/MRI brain attending the Geriatric Clinic for 18 month period between January 2017 and June 2018 were retrospectively reviewed. Their socio-demographic details, MRI-brain finding, F- FDG-PET findings and comorbid illnesses were studied.
A total of 21 patients underwent F-FDG-PET/MRI brain during study period. The mean age was 61.23, SD-8.6 years (range: 36-75 years). Among them 5 (23.8%) had Mild Cognitive Impairment (MCI) and 16 (76.2%) had dementia. Majority of patients had early onset cognitive decline (76.2%). Based on the pattern of hypometabolism, the MCI group had one patient each indicative of AD, Semantic-Frontotemporal dementia (Semantic-FTD), mixed Alzheimer's dementia (AD + FTD) and two patients had patterns suggestive of Behaviour Variant of FTD (Bv-FTD). In Dementia group the pattern of hypometabolism was indicative of Bv-FTD in seven, AD in four, Posterior Cortical Atrophy (PCA) in one, Semantic-FTD in one, Mixed AD-Diffuse Lewy Body Dementia (DLBD) in one and no specific pattern in two patients. MRI and 18 F-FDG-PET brain had concordance in 9 (56.26%) patients.
F-FDG-PET/MRI helped in overall clinical diagnosis and management in 19 (90.5%) patients especially with early onset dementia. In MCI group it indicated underlying aetiology and in dementia group it helped in subtyping.
The study supports the role of F-FDG-PET/MRI as an emerging diagnostic tool to assist in dementia evaluation in India.
氟代脱氧葡萄糖正电子发射断层扫描（F-FDG-PET）是一种潜在的敏感生物标志物，可指示神经元损伤。F-FDG-PET 已被证明在痴呆症分型中具有一定的作用。本机构研究了在评估痴呆症中同时进行 F-FDG-PET 和 MRI-脑检查的效果。
回顾性分析了 2017 年 1 月至 2018 年 6 月期间在老年科就诊并接受 18 F-FDG-PET/MRI 脑检查的患者的病例资料。研究了他们的社会人口学特征、MRI 脑结果、F-FDG-PET 结果和合并症。
研究期间共有 21 名患者接受了 F-FDG-PET/MRI 脑检查。平均年龄为 61.23 岁，标准差为 8.6 岁（范围：36-75 岁）。其中 5 名（23.8%）患有轻度认知障碍（MCI），16 名（76.2%）患有痴呆症。大多数患者的认知衰退始于早期（76.2%）。根据代谢低下的模式，MCI 组中有 1 例为 AD、语义性额颞叶痴呆（Semantic-FTD）、混合性阿尔茨海默病痴呆（AD + FTD），2 例为行为变异额颞叶痴呆（Bv-FTD）。在痴呆症组中，7 例为 Bv-FTD、4 例为 AD、1 例为后部皮质萎缩（PCA）、1 例为语义性额颞叶痴呆、1 例为混合性 AD-弥漫性路易体痴呆（DLBD）、2 例无特定模式。9 例（56.26%）患者的 MRI 和 18 F-FDG-PET 脑结果具有一致性。
F-FDG-PET/MRI 脑检查在 19 例（90.5%）患者的整体临床诊断和管理中提供了帮助，特别是对于早期发病的痴呆症患者。在 MCI 组中，它提示了潜在的病因，在痴呆症组中，它有助于分型。
该研究支持 F-FDG-PET/MRI 作为一种新兴的诊断工具，可协助印度进行痴呆症评估。
