Lee Jonathan, Renslo Jonathan, Wong Kasen, Clifford Thomas G, Beutler Bryce D, Kim Paul E, Gholamrezanezhad Ali
Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Diagnostics (Basel). 2024 Mar 10;14(6):585. doi: 10.3390/diagnostics14060585.
Dementia is a significant global health issue that is exacerbated by an aging population. Imaging plays an established role in the evaluation of patients with neurocognitive disorders such as dementia. In current clinical practice, magnetic resonance imaging (MRI) and positron emission tomography (PET) are primary imaging modalities used separately but in concert to help diagnose and classify dementia. The clinical applications of PET/MRI hybrid imaging in dementia are an active area of research, particularly given the continued emergence of functional MRI (fMRI) and amyloid PET tracers. This narrative review provides a comprehensive overview of the rationale and current evidence for PET/MRI hybrid dementia imaging from 2018 to 2023. Hybrid imaging offers advantages in the accuracy of characterizing neurodegenerative disorders, and future research will need to address the cost of integrated PET/MRI systems compared to stand-alone scanners, the development of new biomarkers, and image correction techniques.
痴呆是一个重大的全球健康问题，老龄化人口加剧了这一问题。影像学在评估痴呆等神经认知障碍患者方面发挥着既定作用。在当前临床实践中，磁共振成像（MRI）和正电子发射断层扫描（PET）是分别使用但协同作用以帮助诊断和分类痴呆的主要影像学方式。PET/MRI混合成像在痴呆中的临床应用是一个活跃的研究领域，特别是考虑到功能磁共振成像（fMRI）和淀粉样蛋白PET示踪剂的不断出现。本叙述性综述全面概述了2018年至2023年PET/MRI混合痴呆成像的基本原理和当前证据。混合成像在表征神经退行性疾病的准确性方面具有优势，未来的研究需要解决与独立扫描仪相比集成PET/MRI系统的成本、新生物标志物的开发以及图像校正技术等问题。
