de Oliveira Amanda Almeida, Davis Destiny, Nunes Kenia Pedrosa
Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, USA.
Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, USA.
Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1117-1122. doi: 10.1016/j.dsx.2019.01.012. Epub 2019 Jan 18.
Pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs) play crucial roles in the underlying mechanisms of metabolic syndrome (MetS). Mainly, these receptors have been suggested to participate in the pathophysiological processes involved in the complications associated with this condition. Therefore, to evolve therapeutic strategies targeting PRRs might be an imperative approach to avoid the development of further complications in human subjects. In this work, we discuss the understanding regarding the roles of PRRs in the pathways of MetS to further describe potential advancements made to target these receptors within this pathology.
模式识别受体（PRR），如Toll样受体（TLR）和NOD样受体（NLR），在代谢综合征（MetS）的潜在机制中发挥着关键作用。主要地，这些受体被认为参与了与该病症相关并发症的病理生理过程。因此，开发针对PRR的治疗策略可能是避免人类受试者出现进一步并发症的必要方法。在这项工作中，我们讨论了对PRR在MetS通路中作用的理解，以进一步描述在该病理情况下针对这些受体所取得的潜在进展。
