总胆红素可独立预测社区居住女性新发代谢综合征。
Total bilirubin independently predicts incident metabolic syndrome among community-dwelling women.
作者信息
Kawamoto Ryuichi, Kikuchi Asuka, Akase Taichi, Ninomiya Daisuke, Kasai Yoshihisa, Ohtsuka Nobuyuki, Kumagi Teru
机构信息
Department of Community Medicine, Ehime University Graduate School of Medicine, Japan; Department of Internal Medicine, Seiyo Municipal Nomura Hospital, Japan.
Department of Internal Medicine, Seiyo Municipal Nomura Hospital, Japan.
出版信息
Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1329-1334. doi: 10.1016/j.dsx.2019.02.009. Epub 2019 Feb 5.
BACKGROUND
Metabolic syndrome (MetS) is related to the increased risk of major cardiovascular diseases (CVD). The link between high serum total bilirubin (TBL) is cross-sectionally related to MetS and its components. However, whether serum TBL predicts incidence of MetS and its components remains inconclusive.
METHODS
The present study included 893 women aged 70 ± 9 years from a rural village. We examined the relationship between serum TBL and MetS based on the modified criteria of the National Cholesterol Education Program's Adult Treatment Panel (NCEP-ATP) III report in a cross-sectional (N = 893) and cohort (N = 288) data.
RESULTS
In the cross-sectional study, serum TBL (β = 0.536, p < 0.001) as well as age, alcohol consumption, exercise habits, history of CVD, SUA, GGT, and ALT was significantly and dependently associated with number of MetS components, but in the cohort study serum TBL was not associated with number of MetS components. Compared with the 1st tertile of serum TBL (0.20-0.55 mg/dL), multivariate-adjusted odds ratio (95% confidence interval) for the 2nd -3rd tertiles of serum TBL (0.54-2.00 mg/dL) was 0.70 (0.51-0.95) in the cross-sectional study and 0.41 (0.21-0.81) in the cohort study.
CONCLUSIONS
Our data demonstrated an independently negative association between serum TBL and MetS in Japanese community-dwelling women.
背景
代谢综合征（MetS）与主要心血管疾病（CVD）风险增加相关。血清总胆红素（TBL）升高与MetS及其组分存在横断面关联。然而，血清TBL是否能预测MetS及其组分的发病率仍无定论。
方法
本研究纳入了来自一个乡村的893名70±9岁的女性。我们基于美国国家胆固醇教育计划成人治疗小组（NCEP-ATP）III报告的修订标准，在横断面（N = 893）和队列（N = 288）数据中研究了血清TBL与MetS之间的关系。
结果
在横断面研究中，血清TBL（β = 0.536，p < 0.001）以及年龄、饮酒、运动习惯、CVD病史、血尿酸（SUA）、γ-谷氨酰转移酶（GGT）和丙氨酸转氨酶（ALT）与MetS组分数量显著且独立相关，但在队列研究中血清TBL与MetS组分数量无关。与血清TBL第一三分位数（0.20 - 0.55mg/dL）相比，血清TBL第二至第三三分位数（0.54 - 2.00mg/dL）的多变量调整比值比（95%置信区间）在横断面研究中为0.70（0.51 - 0.95），在队列研究中为0.41（0.21 - 0.81）。
结论
我们的数据表明，在日本社区居住女性中，血清TBL与MetS之间存在独立的负相关。
Zotero 插件