Centre of Maritime Health and Society, Department of Public Health, University of Southern Denmark, Esbjerg, Denmark.
Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC Public Health. 2020 Apr 5;20(1):442. doi: 10.1186/s12889-020-08466-2.
There is still controversy over the clinical interpretation of the association between metabolic syndrome (MetS) and serum uric acid (SUA) levels. Therefore, the aim of this study was to investigate the association of SUA levels with MetS and other cardio-metabolic risk factors (CMRF) in seafarers working on tankers.
This cross-sectional study was conducted in 2015 and included 234 male seafarers working on tankers. The participants were divided into three groups based on the tertiles of SUA. The report from of the National Committee of Obesity was used to define the MetS. The relationship between SUA, CMRF and MetS adjusted for age, educational level, job history, shift work, smoking and BMI was assessed by logistic regression analysis.
The subjects were aged 36.0 ± 10.3 years (mean ± SD). A notable upward trend was observed in mean weight, body mass index (BMI), triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL) and very low-density lipoprotein (VLDL) as tertiles of SUA increased (P < 0.001). In all models of the logistic regression analyses, the odds ratio (OR) of high TG for participants in the 3rd tertile of SUA was four times higher than that for participants in the 1st tertile of SUA (P < 0.001). The odds ratio of high TC and the SUA levels increased, so that the odds ratio of high TC for participants in the 2nd tertile was 2.47 (95% CI: 1.10-5.53) (P < 0.05) as compared with that for participants in the 1st tertile. Significant association was observed between MetS and the levels of SUA; 6.10 (95% CI: 1.77-20.94) (P < 0.05).
Findings revealed that SUA levels were associated with MetS, high TG and high TC. Therefore, it is recommended that clinical attention should be given to symptoms related to elevated SUA - being one of the most important remediable risk factors for MetS - in the annual medical examinations of seafarers.
代谢综合征（MetS）与血清尿酸（SUA）水平之间的临床关联仍存在争议。因此，本研究旨在探讨海员血清尿酸水平与 MetS 及其他心血管代谢危险因素（CMRF）的关系。
本横断面研究于 2015 年进行，纳入了 234 名在油轮上工作的男性海员。根据 SUA 的三分位值将参与者分为三组。采用全国肥胖委员会的报告定义 MetS。采用 logistic 回归分析评估校正年龄、教育程度、工作史、轮班工作、吸烟和 BMI 后，SUA 与 CMRF 和 MetS 之间的关系。
受试者年龄为 36.0±10.3 岁（均值±标准差）。随着 SUA 三分位值的升高，平均体重、体重指数（BMI）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）呈显著上升趋势（P<0.001）。在 logistic 回归分析的所有模型中，第 3 三分位 SUA 组的高 TG 的比值比（OR）是第 1 三分位 SUA 组的 4 倍（P<0.001）。TC 水平与 OR 呈正相关，因此，第 2 三分位的 TC 水平的 OR 为 2.47（95%CI：1.10-5.53）（P<0.05），高于第 1 三分位的 OR。MetS 与 SUA 水平显著相关；OR 为 6.10（95%CI：1.77-20.94）（P<0.05）。
研究结果表明，SUA 水平与 MetS、高 TG 和高 TC 有关。因此，建议在海员的年度体检中，临床医生应注意与 SUA 升高相关的症状，SUA 是 MetS 最重要的可纠正危险因素之一。
