Grosse-Thie Charlotte, Vogel Mandy, Baber Ronny, Ceglarek Uta, Kiess Wieland
LIFE Child, LIFE Leipzig Research Center for Civilization Diseases, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103 Leipzig, Germany.
Center for Pediatric Research (CPL), Department of Women and Child Health, Hospital for Children and Adolescents, Leipzig University, Liebigstrasse 20a, 04103 Leipzig, Germany.
Metabolites. 2024 Jul 19;14(7):393. doi: 10.3390/metabo14070393.
It is assumed that bilirubin is hormonally regulated and influences weight development by preventing weight gain. However, studies in healthy infants are limited. The present study established reference values for bilirubin and investigated whether bilirubin levels are significantly associated with body weight, levels of ferritin and transferrin as well as steroid hormone levels in a study population of three- and six-month-old healthy infants. Data from a total of 411 study visits from the LIFE Child study (Leipzig, Germany) were analyzed. Associations were examined using linear regression analyses. Besides laboratory parameters, anthropometric data were gathered. We found statistically significant associations between body weight and bilirubin levels. In girls, we observed additional associations between bilirubin levels and both ferritin and transferrin concentrations at three months of age. At six months, steroid hormone levels were significantly associated with concentrations of total and indirect bilirubin, with effects differing by sex. Our study thus confirms associations already reported from animal studies and studies in adult populations. Furthermore, we showed that these associations already exist in the first year of life, are influenced by sex and age and, further, depend on the bilirubin type. Our results provide reference values for bilirubin and assist, therefore, in interpreting bilirubin levels in infancy.
假定胆红素受激素调节，并通过阻止体重增加来影响体重发育。然而，针对健康婴儿的研究有限。本研究确立了胆红素的参考值，并在一个由三个月和六个月大的健康婴儿组成的研究群体中，调查了胆红素水平是否与体重、铁蛋白和转铁蛋白水平以及类固醇激素水平显著相关。对来自德国莱比锡LIFE儿童研究的总共411次研究访视的数据进行了分析。使用线性回归分析来检验相关性。除了实验室参数外，还收集了人体测量数据。我们发现体重与胆红素水平之间存在统计学上的显著关联。在女孩中，我们观察到三个月大时胆红素水平与铁蛋白和转铁蛋白浓度之间还存在关联。在六个月时，类固醇激素水平与总胆红素和间接胆红素浓度显著相关，且影响因性别而异。因此，我们的研究证实了动物研究和成人研究中已报道的相关性。此外，我们表明这些相关性在生命的第一年就已存在，受性别和年龄影响，而且还取决于胆红素类型。我们的结果提供了胆红素的参考值，因此有助于解释婴儿期的胆红素水平。
