Musambil Mohthash, Siddiqui Khalid
Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1629-1632. doi: 10.1016/j.dsx.2019.03.017. Epub 2019 Mar 16.
Type 2 diabetes (T2D) is a polygenic and multi-factorial complex disease, the challenge to find genetic markers that could explain the risk of development of this disease still remains unresolved. The Arab region is one among the populations with a high prevalence of T2D and a large number of studies have been carried out in exploring the genetic factors associated with T2D risk.
To summarize the recent developments in the Arab world based on the recent studies that had looked into genetic factors associated with the development of T2D in the Arab populations.
A systematic literature search was conducted to identify studies published between 2015 and 2018 reporting genetic factors or polymorphisms associated with the risk of T2D in the Arab world. The online databases PubMed and Web of Science were used to perform the literature search.
The present study has evaluated 14 studies published during the year 2015-2018. Studies from Egypt, Iraq, Jordan, Oman, Qatar, Saudi Arabia, Tunisia, and United Arab Emirates had been explored studying the associations of GIPR, ADIPOQ, FTO, (GRCh38.p12), MLXIP, AKNAD1, KCNJ11 CDKAL1, CDKN2A/2B, TCF7L2, ACE, SNAP25, ELMO1, VDR, KCTD8, GABRA4 and PRKD1 genes with T2D development.
2型糖尿病（T2D）是一种多基因、多因素的复杂疾病，寻找能够解释该疾病发生风险的遗传标记这一挑战仍未得到解决。阿拉伯地区是T2D患病率较高的人群之一，并且已经开展了大量研究来探索与T2D风险相关的遗传因素。
基于近期对阿拉伯人群中与T2D发生相关的遗传因素的研究，总结阿拉伯世界的最新进展。
进行系统的文献检索，以识别2015年至2018年期间发表的报告阿拉伯世界中与T2D风险相关的遗传因素或多态性的研究。使用在线数据库PubMed和Web of Science进行文献检索。
本研究评估了2015年至2018年期间发表的14项研究。对来自埃及、伊拉克、约旦、阿曼、卡塔尔、沙特阿拉伯、突尼斯和阿拉伯联合酋长国的研究进行了探索，研究了GIPR、ADIPOQ、FTO、（GRCh38.p12）、MLXIP、AKNAD1、KCNJ11、CDKAL1、CDKN2A/2B、TCF7L2、ACE、SNAP25、ELMO1、VDR、KCTD8、GABRA4和PRKD1基因与T2D发生的关联。
