Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Hum Genomics. 2022 Apr 2;16(1):11. doi: 10.1186/s40246-022-00383-2.
Diabetes is a chronic metabolic disorder that leads to the dysfunction of various tissues and organs, including eyes, kidneys, and cardiovascular system. According to the World Health Organization, diabetes prevalence is 8.8% globally among whom about 90% of cases are type 2 diabetes. There are not any significant clinical manifestations in the primary stages of diabetes. Therefore, screening can be an efficient way to reduce the diabetic complications. Over the recent decades, the prevalence of diabetes has increased alarmingly among the Middle East population, which has imposed exorbitant costs on the health care system in this region. Given that the genetic changes are among the important risk factors associated with predisposing people to diabetes, we examined the role of single-nucleotide polymorphisms (SNPs) in the pathogenesis of diabetes among Middle East population. In the present review, we assessed the molecular pathology of diabetes in the Middle East population that paves the way for introducing an efficient SNP-based diagnostic panel for diabetes screening among the Middle East population. Since, the Middle East has a population of 370 million people; the current review can be a reliable model for the introduction of SNP-based diagnostic panels in other populations and countries around the world.
糖尿病是一种慢性代谢紊乱，可导致包括眼睛、肾脏和心血管系统在内的各种组织和器官的功能障碍。根据世界卫生组织的数据，全球糖尿病的患病率为 8.8%，其中约 90%的病例为 2 型糖尿病。糖尿病的早期阶段没有明显的临床症状。因此，筛查可能是减少糖尿病并发症的有效方法。近几十年来，中东地区的糖尿病患病率惊人地上升，这给该地区的医疗保健系统带来了高昂的成本。鉴于遗传变化是导致人们易患糖尿病的重要危险因素之一，我们研究了单核苷酸多态性 (SNP) 在中东人群糖尿病发病机制中的作用。在本综述中，我们评估了中东人群中糖尿病的分子病理学，为在中东人群中引入基于 SNP 的糖尿病筛查的有效诊断面板铺平了道路。由于中东地区有 3.7 亿人口；因此，本综述可以为在其他人群和世界各地的国家引入基于 SNP 的诊断面板提供可靠的模型。
