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糖尿病患者的经皮氧分压(TcPO)与溃疡结局:是否存在相关性?

Transcutaneous oxygen pressure (TcPO) and ulcer outcome in diabetic patients: Is there any correlation?

作者信息

Zubair Mohammad, Ahmad Jamal

机构信息

Department of Medical Microbiology, Faculty of Medicine, University of Tabuk, Tabuk, 71491, Saudi Arabia.

Rajiv Gandhi Centre for Diabetes and Endocrinology, Faculty of Medicine, J.N. Medical College, Aligarh Muslim University, Aligarh, 202002, India.

出版信息

Diabetes Metab Syndr. 2019 Mar-Apr;13(2):953-958. doi: 10.1016/j.dsx.2018.12.008. Epub 2018 Dec 19.

Abstract

BACKGROUND

Due to poor blood circulation, the prevalence of foot ulcer is extensively reported among diabetic patients. Diabetic neuropathy is the critical factor of diabetes that can affect the nerves.

OBJECTIVE

To examine the outcomes and correlation between TcPO2 and ulcer outcomes among diabetic patients.

MATERIAL AND METHODS

A prospective cohort design has been employed to compare and correlate TcPO2 group with ulcer outcomes. A total of 192 patients were enrolled, who underwent diagnosis for ulcer outcome. Descriptive analysis and Pearson Correlation were used for data analysis via SPSS version 20.

RESULTS

The prevalence of minor amputation among diabetic patients in 25-40 mmHg 75 (85.22%) and >40 mmhG 73 (84.88%) group is reported for ulcer outcome. Mostly diabetic patients were healed with intact skin (male = 36, female = 73), and improved ulcer healing (male = 23, female = 43). Correlation between ulcer size (p = .016), ABI (p = .044), TBI (p = .000), Adiponectin (p = .009), HbA1c (p = .033), and S. creatinine (p = .025) was significant with TcpO2 group.

CONCLUSIONS

The study concluded that there is a positive and significant correlation between TcPO2 group and ulcer outcome. There is a positive association between TcPO2 baseline and degree of ulcer healing with intact skin.

摘要

背景

由于血液循环不良,糖尿病患者足部溃疡的患病率被广泛报道。糖尿病神经病变是糖尿病可影响神经的关键因素。

目的

研究糖尿病患者经皮氧分压(TcPO2)与溃疡愈合结果之间的关系及相关结果。

材料与方法

采用前瞻性队列设计,比较TcPO2组与溃疡愈合结果,并进行相关性分析。共纳入192例接受溃疡愈合结果诊断的患者。通过SPSS 20版软件进行描述性分析和Pearson相关性分析。

结果

报告了糖尿病患者溃疡愈合结果,25 - 40 mmHg组75例(85.22%)和>40 mmHg组73例(84.88%)行小截肢术。大多数糖尿病患者皮肤愈合完好(男性 = 36例,女性 = 73例),溃疡愈合情况改善(男性 = 23例,女性 = 43例)。溃疡大小(p = 0.016)、踝肱指数(ABI,p = 0.044)、经皮胫后动脉指数(TBI,p = 0.000)、脂联素(p = 0.009)、糖化血红蛋白(HbA1c,p = 0.033)和血肌酐(p = 0.025)与TcPO2组显著相关。

结论

该研究得出结论,TcPO2组与溃疡愈合结果之间存在显著正相关。TcPO2基线与皮肤愈合完好的溃疡愈合程度之间存在正相关。

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