体重指数与血清钙和磷水平的关联。
Association of body mass index with serum calcium and phosphate levels.
作者信息
Jafari-Giv Zahra, Avan Amir, Hamidi Farshid, Tayefi Maryam, Ghazizadeh Hamideh, Ghasemi Faeze, Javandoost Ali, Farjami Zahra, Mouhebati Mohsen, Safarian Mohammad, Parizadeh Seyyed Mohammad Reza, Saberi-Karimian Maryam, Ferns Gordon A, Ghayour-Mobarhan Majid
机构信息
Doctor of Veterinary Medicine, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Department of Modern Science and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Diabetes Metab Syndr. 2019 Mar-Apr;13(2):975-980. doi: 10.1016/j.dsx.2018.12.017. Epub 2019 Jan 11.
OBJECTIVE
It has been shown that several environmental and physiological factors can affect on the serum levels of calcium and phosphate. The objective of the present study was explored the relationship between serum calcium and phosphate levels with anthropometric and hematological markers.
METHODS
908 subjects were recruited from the Mashhad stroke and heart atherosclerosis disorder (MASHHAD) program. Anthropometric parameters, liver/kidney function tests (e.g., Urea nitrogen, creatinine, urea and uric acid, creatinine, AST, ALT) were determined in all participants. Serum concentrations of calcium and phosphate were measured using Autoanalyzer BT3000P (Pars Azmoon kit, Tehran, Iran). SPSS software was used for statistical analyses.
RESULTS
We observed that obese subjects had a lower level of serum calcium (p˂0.05). Moreover, a relationship was detected between serum phosphate level and different menopausal status (p˂0.05). Serum calcium and phosphate did not change by increasing age in the population. Additionally, there was a correlation between lymphocyte count with serum phosphate level (p˂0.05). No statistically different were detected for the levels of calcium/phosphate with respect to smoking status, physical activity, lipid profile, liver and renal function markers.
CONCLUSION
We found an association between serum calcium and BMI as well as with serum phosphate and menopausal status.
目的
已有研究表明，多种环境和生理因素会影响血清钙和磷水平。本研究的目的是探讨血清钙和磷水平与人体测量学及血液学指标之间的关系。
方法
从马什哈德中风与心脏动脉粥样硬化疾病（MASHHAD）项目中招募了908名受试者。测定了所有参与者的人体测量参数、肝/肾功能测试指标（如尿素氮、肌酐、尿素和尿酸、肌酐、谷草转氨酶、谷丙转氨酶）。使用自动分析仪BT3000P（伊朗德黑兰Pars Azmoon试剂盒）测定血清钙和磷浓度。采用SPSS软件进行统计分析。
结果
我们观察到肥胖受试者的血清钙水平较低（p<0.05）。此外，还检测到血清磷水平与不同绝经状态之间存在关联（p<0.05）。在该人群中，血清钙和磷水平不会随年龄增长而变化。此外，淋巴细胞计数与血清磷水平之间存在相关性（p<0.05）。在吸烟状况、身体活动、血脂谱、肝肾功能指标方面，钙/磷水平未检测到统计学差异。
结论
我们发现血清钙与体重指数之间以及血清磷与绝经状态之间存在关联。
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