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合成 DNA 和 RNA 编程。

Synthetic DNA and RNA Programming.

机构信息

Department of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada.

Department of Chemistry, The University of Western Ontario, London, ON N6A 5C1, Canada.

出版信息

Genes (Basel). 2019 Jul 11;10(7):523. doi: 10.3390/genes10070523.

Abstract

Synthetic biology is a broad and emerging discipline that capitalizes on recent advances in molecular biology, genetics, protein and RNA engineering as well as omics technologies. Together these technologies have transformed our ability to reveal the biology of the cell and the molecular basis of disease. This Special Issue on "Synthetic RNA and DNA Programming" features original research articles and reviews, highlighting novel aspects of basic molecular biology and the molecular mechanisms of disease that were uncovered by the application and development of novel synthetic biology-driven approaches.

摘要

合成生物学是一个广泛且新兴的学科,它利用分子生物学、遗传学、蛋白质和 RNA 工程以及组学技术的最新进展。这些技术共同改变了我们揭示细胞生物学和疾病分子基础的能力。本期关于“合成 RNA 和 DNA 编程”的特刊收录了原创研究文章和综述,突出了应用和开发新型合成生物学驱动的方法所揭示的基础分子生物学和疾病分子机制的新方面。

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Pathways to disease from natural variations in human cytoplasmic tRNAs.人类细胞质 tRNA 自然变异导致疾病的途径。
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