葡萄球菌肽聚糖的促有丝分裂活性。
Mitogenic activity of staphylococcal peptidoglycan.
作者信息
Dziarski R, Dziarski A
出版信息
Infect Immun. 1979 Mar;23(3):706-10. doi: 10.1128/iai.23.3.706-710.1979.
Abstract
Staphylococcus aureus peptidoglycan displayed a marked dose-dependent mitogenic activity for mouse splenocytes and human peripheral blood lymphocytes in vitro, as measured by increased [3H]thymidine incorporation. Similarly it was mitogenic for athymic nude mouse spleen cells, whereas no blastogenic effect was observed in T cell-enriched and B cell-depleted mouse lymphocyte cultures. These data demonstrate that peptidoglycan-responding cells in mouse spleen cell cultures are B lymphocytes.
摘要
金黄色葡萄球菌肽聚糖在体外对小鼠脾细胞和人外周血淋巴细胞显示出显著的剂量依赖性促有丝分裂活性，这通过[3H]胸腺嘧啶核苷掺入增加来测定。同样，它对无胸腺裸鼠脾细胞有促有丝分裂作用，而在富含T细胞和去除B细胞的小鼠淋巴细胞培养物中未观察到致细胞分裂效应。这些数据表明，小鼠脾细胞培养物中对肽聚糖有反应的细胞是B淋巴细胞。
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