来自金黄色葡萄球菌的可溶性肽聚糖是一种小鼠B淋巴细胞有丝分裂原。
Soluble peptidoglycan from Staphylococcus aureus is a murine B-lymphocyte mitogen.
作者信息
Babu U M, Zeiger A R
出版信息
Infect Immun. 1983 Dec;42(3):1013-6. doi: 10.1128/iai.42.3.1013-1016.1983.
Abstract
Soluble peptidoglycan from Staphylococcus aureus has been shown to be capable of causing murine B lymphocytes from the spleen to proliferate and to secrete immunoglobulins in both an in vitro and an in vivo assay. The optimal concentration in vitro was between 33 and 100 micrograms/ml. A 3-day incubation with soluble peptidoglycan was more stimulatory than was a 1- or 2-day incubation. Removal of most of the T lymphocytes with anti-theta serum did not result in any significant change in the mitogenic activity of soluble peptidoglycan on the remaining B cells.
摘要
已证明，来自金黄色葡萄球菌的可溶性肽聚糖在体外和体内试验中均能使脾脏中的小鼠B淋巴细胞增殖并分泌免疫球蛋白。体外的最佳浓度在33至100微克/毫升之间。与可溶性肽聚糖进行3天孵育比1天或2天孵育更具刺激性。用抗θ血清去除大部分T淋巴细胞后，可溶性肽聚糖对剩余B细胞的促有丝分裂活性没有任何显著变化。
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