He Qian, Bao Mengdi, Hass Kenneth, Lin Wenxia, Qin Peiwu, Du Ke
Department of Mechanical Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA.
Precision Medicine and Public Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Shenzhen 518057, China.
Diagnostics (Basel). 2019 Jul 13;9(3):75. doi: 10.3390/diagnostics9030075.
Barcode technology has a broad spectrum of applications including healthcare, food security, and environmental monitoring, due to its ability to encode large amounts of information. With the rapid development of modern molecular research, barcodes are utilized as a reporter with different molecular combinations to label many biomolecular targets, including genomic and metabolic elements, even with multiplex targeting. Along with the advancements in barcoded bioassay, the improvements of various designs of barcode components, encoding and decoding strategies, and their portable adoption are indispensable in satisfying multiple purposes, such as medical confirmation and point-of-care (POC) testing. This perspective briefly discusses the current direction and progress of barcodes development and provides a hypothesis for barcoded bioassay in the near future.
条形码技术具有广泛的应用，包括医疗保健、食品安全和环境监测，这得益于其能够编码大量信息的能力。随着现代分子研究的迅速发展，条形码被用作一种报告分子，与不同的分子组合一起用于标记许多生物分子靶点，包括基因组和代谢成分，甚至可进行多重靶向。随着条形码生物测定技术的进步，条形码组件的各种设计、编码和解码策略的改进以及它们的便携式应用对于满足多种目的（如医学确认和即时检测（POC））而言是不可或缺的。本文简要讨论了条形码技术发展的当前方向和进展，并对不久的将来条形码生物测定技术提出了一种假设。
