Department of Breast Oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine; Address: 651 East Dongfeng Road, Guangzhou, PR China.
Department of Minimally Invasive Interventional Radiology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine; Address: 651 East Dongfeng Road, Guangzhou, PR China.
Epigenomics. 2019 Aug;11(10):1163-1176. doi: 10.2217/epi-2019-0093. Epub 2019 Jul 24.
To investigate the role of circRNAs in triple-negative breast cancer (TNBC) and the underlying mechanisms. We performed circRNA microarrays to explore the expression profiles of TNBC cell lines. Experiments and were conducted to explore the effects of circPLK1 on tumor proliferation and metastasis as well as the interaction between circPLK1, miR-296-5p and in TNBC. CircPLK1 was significantly upregulated in TNBC and associated with poor survivals. CircPLK1 knockdown inhibited cell growth and invasion as well as tumor occurrence and metastasis . CircPLK1-miR-296-5p- axis regulates tumor progression by ceRNA mechanism in TNBC, indicating that circPLK1 may serve as a prognostic factor and novel therapeutic target for TNBC.
为了探究 circRNAs 在三阴性乳腺癌（TNBC）中的作用及其潜在机制。我们进行了 circRNA 微阵列分析，以探讨 TNBC 细胞系的表达谱。实验和实验分别用于探讨 circPLK1 对肿瘤增殖和转移的影响，以及 circPLK1、miR-296-5p 和在 TNBC 中的相互作用。circPLK1 在 TNBC 中显著上调，并与不良预后相关。circPLK1 敲低抑制细胞生长和侵袭，以及肿瘤发生和转移。circPLK1-miR-296-5p-轴通过 TNBC 中的 ceRNA 机制调节肿瘤进展，表明 circPLK1 可能作为 TNBC 的预后因素和新的治疗靶点。
