CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression.

To investigate the role of circRNAs in triple-negative breast cancer (TNBC) and the underlying mechanisms. We performed circRNA microarrays to explore the expression profiles of TNBC cell lines. Experiments and were conducted to explore the effects of circPLK1 on tumor proliferation and metastasis as well as the interaction between circPLK1, miR-296-5p and in TNBC. CircPLK1 was significantly upregulated in TNBC and associated with poor survivals. CircPLK1 knockdown inhibited cell growth and invasion as well as tumor occurrence and metastasis . CircPLK1-miR-296-5p- axis regulates tumor progression by ceRNA mechanism in TNBC, indicating that circPLK1 may serve as a prognostic factor and novel therapeutic target for TNBC.