Lee Kevin C, Eisig Sidney B, Chuang Sung-Kiang, Perrino Michael A
Division of Oral and Maxillofacial Surgery, New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Department of Oral and Maxillofacial Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Cleft Palate Craniofac J. 2020 Jan;57(1):99-104. doi: 10.1177/1055665619864735. Epub 2019 Jul 23.
The purpose of this study was to determine whether performing mandibular distraction osteogenesis (MDO) during the neonatal period increased inpatient complications as measured through health-care burden.
This was a retrospective cohort study of the Kids' Inpatient Database from 2000 to 2011. Infants receiving MDO prior to 12 months of age were included. The primary study predictor was distraction age, classified as either neonatal or non-neonatal. Secondary predictors were patient demographics, hospitalization characteristics, diagnoses, and procedures. The outcomes were the number of procedures performed, postoperative length of stay (pLOS), hospital charges, and the discharge transfer rate. Outcomes were compared between the primary predictors using χ and independent 2-sample tests. Multiple linear and logistic regression models were created using clinically relevant predictors to assess the independent effect of neonatal age on each outcome.
The study sample contained 102 patients, of who 50 (49.0%) were distracted in the neonatal period. Neonatal MDO patients were more likely to have a cleft palate (86.0% vs 55.8%; < .001) and present with feeding difficulties (38.0% vs 19.2%; = .036) that were treated through total parenteral nutrition (26.0% vs 9.6%; = .030) but otherwise did not have significantly different characteristics compared to non-neonatal patients. The multiple regression models confirmed that neonatal age did not influence any of the study outcomes, although other secondary predictors were found to influence the pLOS, hospital charges, and number of inpatient procedures.
Neonatal MDO was not associated with increased complications. At experienced centers, neonatal status should not be considered a contraindication to treatment.
本研究旨在确定在新生儿期进行下颌骨牵张成骨术(MDO)是否会增加住院并发症,该并发症通过医疗负担来衡量。
这是一项对2000年至2011年儿童住院数据库的回顾性队列研究。纳入12个月龄前接受MDO的婴儿。主要研究预测因素是牵张年龄,分为新生儿期或非新生儿期。次要预测因素包括患者人口统计学特征、住院特征、诊断和手术。结果指标为手术操作次数、术后住院时间(pLOS)、住院费用和出院转诊率。使用χ²检验和独立两样本t检验比较主要预测因素之间的结果。使用临床相关预测因素创建多元线性和逻辑回归模型,以评估新生儿年龄对每个结果的独立影响。
研究样本包括102例患者,其中50例(49.0%)在新生儿期接受牵张。新生儿期接受MDO的患者更易发生腭裂(86.0%对55.8%;P<0.001),并存在喂养困难(38.0%对19.2%;P = 0.036),需通过全胃肠外营养治疗(26.0%对9.6%;P = 0.030),但与非新生儿期患者相比,其他方面特征无显著差异。多元回归模型证实,尽管发现其他次要预测因素会影响pLOS、住院费用和住院手术次数,但新生儿年龄并未影响任何研究结果。
新生儿期MDO与并发症增加无关。在经验丰富的中心,不应将新生儿状态视为治疗的禁忌证。