González-Castro Thelma Beatriz, Hernández-Díaz Yazmín, Pérez-Hernández Nonanzit, Tovilla-Zárate Carlos Alfonso, Juárez-Rojop Isela Esther, López-Narvaez María Lilia, Blachman-Braun Ruben, Posadas-Sánchez Rosalinda, Vargas-Alarcón Gilberto, García-Flores Esbeidy, Cazarín-Santos Benny Giovanni, Borgonio-Cuadra Verónica Marusa, Reyes-López Pedro A, Rodríguez-Pérez José Manuel
Multidisciplinary Academic Division of Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco, Mexico.
Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
EXCLI J. 2019 Jun 7;18:331-355. doi: 10.17179/excli2019-1248. eCollection 2019.
Cardiovascular diseases (CVD) are group of complex and multifactorial pathologies, in which interleukin-6 () gene polymorphisms have been associated with several components of the CVD. Thus, in this study, we thoroughly reviewed and meta-analyzed evidence on the association between the (rs1800795) gene polymorphism and CVD. We systematically searched in the PubMed, Web of Sciences, and Scopus databases. The analyses were performed using five study groups based on (1) a combined pool of the overall populations, (2) the country of birth, (3) the continent of birth, (4) the diagnosis and (5) both location (country or continent) and diagnosis. The analysis included the allelic, homozygote, heterozygote, dominant and recessive models. The meta-analysis showed that -174 (rs1800795) is a risk factor for CVD (: OR=1.06, CI 95%=1.02-1.10. Z p value <0.0001; homozygous: OR=1.11, CI 95%=1.03-1.19, Z p value= 0.002; : OR=1.08, CI 95%=1.03-1.21, Z p value= 0.003; : OR= 1.12, CI 95%= 1.07-1.18, Z p value= 0.001) and that this risk increases in the Chinese population. Additionally, we found that carriers of the allele of 174 (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study. Using robust data, we found that (rs1800795) -174 gene polymorphism is associated with CVD risk.
心血管疾病（CVD）是一组复杂的多因素病理状况，其中白细胞介素-6（IL-6）基因多态性与心血管疾病的多个组成部分相关。因此，在本研究中，我们全面回顾并荟萃分析了有关IL-6（rs1800795）基因多态性与心血管疾病之间关联的证据。我们在PubMed、科学网和Scopus数据库中进行了系统检索。分析基于以下五个研究组进行：（1）总体人群的合并样本库；（2）出生国家；（3）出生大洲；（4）诊断情况；（5）出生地点（国家或大洲）及诊断情况。分析包括等位基因、纯合子、杂合子、显性和隐性模型。荟萃分析表明，-174（rs1800795）是心血管疾病的一个危险因素（总体：比值比[OR]=1.06，95%置信区间[CI]=1.02-1.10，Z p值<0.0001；纯合子：OR=1.11，95%CI=1.03-1.19，Z p值=0.002；杂合子：OR=1.08，95%CI=1.03-1.21，Z p值=0.003；显性模型：OR=1.12，95%CI=1.07-1.18，Z p值=0.001），且这种风险在中国人群中有所增加。此外，我们发现，在本研究评估的遗传模型下，174（rs1800795）多态性的G等位基因携带者患冠状动脉疾病的风险增加。基于可靠数据，我们发现IL-6（rs1800795）-174基因多态性与心血管疾病风险相关。
