Hongmei Yao, Yongping Jia, Jiyuan Lv
Yao Hongmei, Department of Cardiology, The First Hospital of Shanxi Medical University, No. 85 Xinjiannan Road, Taiyuan 030001, Shanxi, China.
Jia Yongping, Department of Cardiology, The First Hospital of Shanxi Medical University, No. 85 Xinjiannan Road, Taiyuan 030001, Shanxi, China.
Pak J Med Sci. 2016 Jul-Aug;32(4):880-5. doi: 10.12669/pjms.324.9908.
We aimed to evaluate the relationship between IL-6-174G>C, -572G>C and -597G>A polymorphisms and development of coronary artery diseases in a Chinese population.
A total of 275 patients with coronary artery disease and 296 healthy control subjects were collected between January 2013 and November 2014. The IL-6 genotyping for -174G>C, -592G>C and -597G>A polymorphic sites was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) according to the manufacturer instructions.
Using unconditional regression analysis, we observed that the AC and CC genotypes of IL-6 -592A>C were associated with the increased risk of developing coronary artery disease when compared with the AA genotype, and the adjusted ORs (95%CI) were 1.63(1.12-2.38) and 2.70(1.57-4.67), respectively. Additionally, the C allele of IL-6 -592A>C (OR=1.65, 95%CI=1.29-2.11) was correlated with a higher risk of developing coronary artery disease in comparison to the A allele. However, no relationship was found between IL-6-174G>C and -597G>A polymorphisms and coronary artery disease susceptibility.
This study suggests that IL-6 -592G>C polymorphism is correlated with the risk of coronary artery disease. More well-designed prospective studies based on large sample size, multiple SNPs or haplotypes are required to confirm the current findings.
我们旨在评估白细胞介素-6（IL-6）基因-174G>C、-572G>C和-597G>A多态性与中国人群冠状动脉疾病发生之间的关系。
在2013年1月至2014年11月期间，共收集了275例冠状动脉疾病患者和296例健康对照者。根据制造商说明，采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对IL-6基因-174G>C、-592G>C和-597G>A多态性位点进行基因分型。
采用非条件回归分析，我们观察到与AA基因型相比，IL-6 -592A>C的AC和CC基因型与冠状动脉疾病发生风险增加相关，调整后的比值比（95%置信区间）分别为1.63（1.12 - 2.38）和2.70（1.57 - 4.67）。此外，与A等位基因相比，IL-6 -592A>C的C等位基因（比值比=1.65，95%置信区间=1.29 - 2.11）与冠状动脉疾病发生风险更高相关。然而，未发现IL-6 -174G>C和-597G>A多态性与冠状动脉疾病易感性之间存在关联。
本研究提示IL-6 -592G>C多态性与冠状动脉疾病风险相关。需要更多基于大样本量、多个单核苷酸多态性（SNP）或单倍型的精心设计的前瞻性研究来证实当前的发现。
