Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA.
Department of Physics, Oakland University, Rochester, Michigan, USA.
Stroke Vasc Neurol. 2019 May 10;4(2):90-92. doi: 10.1136/svn-2018-000203. eCollection 2019 Jul.
Diabetes mellitus (DM) is a common metabolic disease in the middle-aged and older population, and is associated with cognitive impairment and an increased risk of developing dementia. The glymphatic system is a recently characterised brain-wide cerebrospinal fluid and interstitial fluid drainage pathway that enables the clearance of interstitial metabolic waste from the brain parenchyma. Emerging data suggest that DM and ageing impair the glymphatic system, leading to accumulation of metabolic wastes including amyloid-β within the brain parenchyma, and consequently provoking cognitive dysfunction. In this review, we concisely discuss recent findings regarding the role of the glymphatic system in DM and ageing associated cognitive impairment.
糖尿病（DM）是中老年人常见的代谢性疾病，与认知障碍和痴呆风险增加有关。糖质新生系统是最近被描述的脑内脑脊液和间质液引流途径，可清除脑实质中的间质代谢废物。新出现的数据表明，DM 和衰老会损害糖质新生系统，导致代谢废物（包括脑实质中的淀粉样蛋白-β）的积累，并因此引发认知功能障碍。在这篇综述中，我们简要讨论了糖质新生系统在 DM 和与衰老相关的认知障碍中的作用的最新发现。
