Botha Heike, Jennings Samuel Hollis, Press Saya A, Istvan Stephanie A
ECC Resident at The Veterinary Specialty Hospital, San Diego, CA, United States.
MSpVM, DACVP Diagnostic Pathologist, Ethos Diagnostic Science, San Diego, CA, United States.
Front Vet Sci. 2019 Jul 9;6:225. doi: 10.3389/fvets.2019.00225. eCollection 2019.
A 12-year-old male neutered Bichon Frise presented to the Emergency Department for stupor and bradycardia after ingestion of chocolate covered 450 mg (90 mg/kg) tetrahydrocannabinol. The patient was hospitalized for supportive care, IV fluid therapy and monitoring in the intensive care unit. During hospitalization the patient became comatose and bradypneic. Treatment with intravenous lipid emulsion (ILE) therapy was instituted to accelerate toxin elimination, reduce the risk of complications related to progressive obtundation and shorten hospitalization time. Five hours after infusion, the patient developed severe respiratory distress and was ultimately euthanized. Post-mortem histologic evaluation of lung revealed severe pulmonary edema consistent with acute respiratory distress syndrome. There are infrequent reports of adverse effects associated with ILE therapy for toxicosis in veterinary medicine despite reports of complications such as acute respiratory distress syndrome in human literature. The purpose of this report is to describe the potential for a severe adverse event after treatment of a toxicosis with ILE therapy.
一只12岁已绝育的雄性比熊犬因摄入含450毫克（90毫克/千克）四氢大麻酚的巧克力后出现昏迷和心动过缓，被送往急诊科。患者住院接受支持治疗、静脉输液治疗，并在重症监护病房进行监测。住院期间，患者陷入昏迷且呼吸缓慢。采用静脉注射脂质乳剂（ILE）疗法以加速毒素清除，降低与进行性意识障碍相关的并发症风险，并缩短住院时间。输液五小时后，患者出现严重呼吸窘迫，最终实施安乐死。死后肺部组织学评估显示严重肺水肿，符合急性呼吸窘迫综合征。尽管人类文献中有关于急性呼吸窘迫综合征等并发症的报道，但兽医医学中关于ILE疗法治疗中毒不良反应的报道并不常见。本报告的目的是描述ILE疗法治疗中毒后发生严重不良事件的可能性。
