McGrory Sarah, Ballerini Lucia, Okely Judith A, Ritchie Stuart J, Doubal Fergus N, Doney Alex S F, Dhillon Baljean, Starr John M, MacGillivray Thomas J, Trucco Emanuele, Wardlaw Joanna M, Deary Ian J
VAMPIRE project, Center for Clinical Brain Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
Department of Psychology, University of Edinburgh, Edinburgh, UK.
Alzheimers Dement (Amst). 2019 Jul 10;11:500-509. doi: 10.1016/j.dadm.2019.04.012. eCollection 2019 Dec.
We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change.
Retinal images from a narrow-age cohort were analyzed using Vessel Assessment and Measurement Platform for Images of the Retina, producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospatial, processing speed, and crystallized cognitive abilities at mean ages 73, 76, and 79 years. We applied multivariate growth curve models to test the association between retinal vascular measurements with cognitive abilities and their changes.
Almost all associations were nonsignificant. In our most parsimonious model, venular asymmetry factor was associated with speed at age 73.
Our null findings suggest that the quantitative retinal parameters applied in this study are not significantly associated with cognitive functioning or cognitive change.
我们测试视网膜血管系统的测量指标是否与认知功能及认知变化相关。
使用视网膜图像血管评估与测量平台对一个年龄范围狭窄的队列的视网膜图像进行分析，在平均年龄72.5岁（标准差=0.7）时生成一系列全面的视网膜血管系统定量测量值。在平均年龄73岁、76岁和79岁时，使用一组多种记忆、视觉空间、处理速度和晶体认知能力测量指标来测量认知能力及变化。我们应用多元增长曲线模型来测试视网膜血管测量值与认知能力及其变化之间的关联。
几乎所有关联均无统计学意义。在我们最简约的模型中，小静脉不对称因子与73岁时的速度相关。
我们的阴性结果表明，本研究中应用的视网膜定量参数与认知功能或认知变化无显著关联。
