Kesebir S, Demirer R M, Tarhan N
Üsküdar University, NPİstanbul Brain Hospital, İstanbul, Turkey.
Üsküdar University, Biomedical Engineering, İstanbul, Turkey.
Heliyon. 2019 Jun 13;5(6):e01898. doi: 10.1016/j.heliyon.2019.e01898. eCollection 2019 Jun.
The aim of this study was to investigate whether differentiation of delta-beta cross frequency coupling (CFC) in bipolar II depressive episode with mixed features and consecutive remission was observed.
8 patient diagnosed bipolar disorder type II, depressive episode with mixed features according to DSM-V, were examined during the current episode, at baseline and end of the third week of lamotrigine use. Hamilton Depression Rating Scale (HDRS) and Mood Disorder Questionnaire (MDQ) were applied to each case at the baseline and end of the third week and QEEG was performed. Temperament was evaluated with TEMPS-A.
dPAC-DB and AAC-DB were significantly higher in FP2 at the end of 3rd weeks of lamotrigine use. A linear relationship was found between F3 dPAC-DB and MDQ scores, before and after treatment. P3 dPAC-DB was correlated with HDRS scores initially only. Cyclothymic temperament scores was found related with dPAC-DB and AAC-DB in F4.
In bipolar disorder, delta-beta CFC was first investigated in this study. CFCs may have a neural projection of the physiopathology of bipolar disorder. At the point we reached in this study, we can show it as both state and trait.
本研究旨在调查是否观察到具有混合特征且连续缓解的双相II型抑郁发作中δ-β交叉频率耦合（CFC）的分化情况。
根据DSM-V诊断为双相II型障碍、具有混合特征的抑郁发作的8例患者，在当前发作期间、基线以及使用拉莫三嗪第三周结束时接受检查。在基线和第三周结束时对每个病例应用汉密尔顿抑郁量表（HDRS）和心境障碍问卷（MDQ），并进行定量脑电图（QEEG）检查。使用TEMPS-A评估气质。
使用拉莫三嗪第三周结束时，FP2处的双相不对称性δ-β耦合（dPAC-DB）和平均绝对耦合（AAC-DB）显著更高。治疗前后，F3处的dPAC-DB与MDQ评分之间存在线性关系。P3处的dPAC-DB最初仅与HDRS评分相关。发现环性气质评分与F4处的dPAC-DB和AAC-DB相关。
在双相情感障碍中，本研究首次对δ-β CFC进行了调查。CFCs可能具有双相情感障碍生理病理学的神经投射。在本研究达到的阶段，我们可以将其显示为状态和特质。
