Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Department of Gastroenterology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Virchows Arch. 2019 Dec;475(6):789-794. doi: 10.1007/s00428-019-02628-3. Epub 2019 Jul 23.
Acinar cell carcinomas (ACCs) of the pancreas are a heterogeneous group of neoplasms showing a wide spectrum of morphological features including acinar, solid, glandular, and trabecular architecture. In addition, uncommon cytological aspects have recently been described and include oncocytic, spindle, clear, and pleomorphic cell types. This wide histological spectrum represents a challenge in the diagnostic task for pathologists. Molecular mechanisms involved in the onset and progression of ACCs are not completely known, but, in general, they differ from those observed in ductal adenocarcinomas or neuroendocrine neoplasms of the pancreas and frequently include alterations in the APC/β-catenin pathway. In the present paper, we describe a new variant of ACC showing thyroid-like follicular features and CTNNB1 mutation. This phenotype needs to be included in the spectrum of morphological presentation of ACC.
胰腺腺泡细胞癌 (ACCs) 是一组异质性肿瘤，表现出广泛的形态学特征，包括腺泡、实性、腺样和小梁状结构。此外，最近还描述了一些不常见的细胞学特征，包括嗜酸细胞性、梭形、透明和多形性细胞类型。这种广泛的组织学谱给病理学家的诊断任务带来了挑战。ACCs 发生和进展中涉及的分子机制尚不完全清楚，但一般来说，它们与在胰腺导管腺癌或神经内分泌肿瘤中观察到的机制不同，并且经常包括 APC/β-连环蛋白途径的改变。在本文中，我们描述了一种具有甲状腺样滤泡特征和 CTNNB1 突变的新型 ACC 变体。这种表型需要包含在 ACC 的形态表现谱中。
