Golan D T, Gilhar A, Wolf V
Isr J Med Sci. 1979 Jun;15(6):507-11.
Attention has been directed lately to antibodies reactive with double-stranded DNA (dsDNA) in systemic lupus erythematosus (SLE) patients, as these antibodies are of considerable diagnostic value and are thought to be involved in the pathogenesis of the disease. In the present study, the clinical and laboratory evaluations of 30 SLE patients in various stages of disease activity were correlated with the levels of anti-DNA antibodies, as detected by the methods of Farr and of Aarden et al. Sera of 65 patients in relapse or remission were examined with both techniques, and a discrepancy was found in only nine sera. In addition, in six patients, a differential analysis of the immunoglobulin classes of anti-dsDNA was performed according to the method of Aarden et al. The data obtained with this assay correlate well with SLE activity and thus may add an important step to the evaluation of SLE patients.
最近，人们的注意力转向了系统性红斑狼疮（SLE）患者体内与双链DNA（dsDNA）反应的抗体，因为这些抗体具有相当大的诊断价值，并且被认为参与了该疾病的发病机制。在本研究中，对30例处于疾病活动不同阶段的SLE患者进行了临床和实验室评估，并将其与通过Farr法和Aarden等人的方法检测到的抗DNA抗体水平进行了关联。使用这两种技术对65例复发或缓解期患者的血清进行了检测，仅在9份血清中发现了差异。此外，根据Aarden等人的方法，对6例患者的抗dsDNA免疫球蛋白类别进行了差异分析。通过该检测获得的数据与SLE活动密切相关，因此可能为SLE患者的评估增加重要的一步。
