Ratzmann K P, Schimke E, Herrmann C, Borngräber G, Meusel K
Zentralstelle für Diabetes und Stoffwechselkrankheiten, Berlin.
Z Gesamte Inn Med. 1988 Mar 1;43(5):122-4.
In 25 newly registered type II diabetics the effect of a sulfonylurea therapy with manilil in contrast to an exclusive dietary treatment on serum triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol as well as the risk indices total cholesterol/HDL cholesterol and LDL cholesterol/HDL cholesterol were investigated within a period of treatment of 6 months. In comparable age, index of body weight and degree of the quality of metabolism (fasting blood glucose, HbA1) there are no differences between dietary treatment and combined diet-manilil-therapy concerning the lipid parameters investigated. There is a significant correlation between the quality of metabolism (fasting blood glucose concentration, HbA1), triglyceride and cholesterol concentration as well as the risk indices total cholesterol/HDL cholesterol and LDL cholesterol/HDL cholesterol. On the other hand, there is no relation between HDL cholesterol and the quality of metabolism. The findings do not speak for the fact that a sulfonylurea therapy is associated with an unfavourable effect on serum lipids, particularly on the HDL cholesterol.
在25例新确诊的II型糖尿病患者中，研究了为期6个月的治疗期间，与单纯饮食治疗相比，使用甲磺氮卓脲进行磺脲类药物治疗对血清甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇以及风险指数总胆固醇/高密度脂蛋白胆固醇和低密度脂蛋白胆固醇/高密度脂蛋白胆固醇的影响。在可比年龄、体重指数和代谢质量程度（空腹血糖、糖化血红蛋白）方面，饮食治疗与饮食-甲磺氮卓脲联合治疗在所研究的脂质参数上没有差异。代谢质量（空腹血糖浓度、糖化血红蛋白）、甘油三酯和胆固醇浓度以及风险指数总胆固醇/高密度脂蛋白胆固醇和低密度脂蛋白胆固醇/高密度脂蛋白胆固醇之间存在显著相关性。另一方面，高密度脂蛋白胆固醇与代谢质量之间没有关系。这些发现并不支持磺脲类药物治疗会对血脂产生不利影响，特别是对高密度脂蛋白胆固醇产生不利影响这一观点。
