Huupponen R K, Viikari J S, Saarimaa H
Diabetes Care. 1984 Nov-Dec;7(6):575-8. doi: 10.2337/diacare.7.6.575.
The relationships between fasting blood glucose, glycosylated hemoglobin A1, and several lipid parameters were studied in 67 non-insulin-dependent diabetic patients (19 men, 48 women) being treated with tolbutamide, chlorpropamide, or glibenclamide. All patients were over 60 yr of age with a mean age of 76.4 +/- 6.7 yr (+/- SD). There were positive associations between fasting blood glucose and serum cholesterol, LDL cholesterol, and serum triglycerides. A strong association between total cholesterol and triglycerides was also evident. Diabetes control and HDL cholesterol did not correlate with each other. A weak inverse correlation existed between fasting blood glucose and the HDL cholesterol/total cholesterol ratio. HDL cholesterol concentrations were low in the diet- and drug-treated diabetic patients. No deleterious sulfonylurea effects on cholesterol, LDL cholesterol, and triglyceride concentrations or HDL cholesterol/total cholesterol ratio were noted.
在67例接受甲苯磺丁脲、氯磺丙脲或格列本脲治疗的非胰岛素依赖型糖尿病患者（19名男性，48名女性）中，研究了空腹血糖、糖化血红蛋白A1与若干脂质参数之间的关系。所有患者年龄均超过60岁，平均年龄为76.4±6.7岁（±标准差）。空腹血糖与血清胆固醇、低密度脂蛋白胆固醇和血清甘油三酯之间存在正相关。总胆固醇与甘油三酯之间也存在明显的强关联。糖尿病控制情况与高密度脂蛋白胆固醇之间无相关性。空腹血糖与高密度脂蛋白胆固醇/总胆固醇比值之间存在弱负相关。饮食和药物治疗的糖尿病患者的高密度脂蛋白胆固醇浓度较低。未观察到磺脲类药物对胆固醇、低密度脂蛋白胆固醇、甘油三酯浓度或高密度脂蛋白胆固醇/总胆固醇比值有不良影响。
