Lung Cancer Center, Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, No. 2 Yinghua Dongjie, Chaoyao District, Beijing 100029, PR China.
Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, PR China.
Future Oncol. 2019 Jul;15(21):2531-2542. doi: 10.2217/fon-2018-0548. Epub 2019 Jul 24.
Lung cancer is the most common cause of cancer-related deaths, with most patients dying with distant metastases. Circulating tumor cells (CTCs) are cancer cells that have disseminated into the peripheral blood from primary or metastatic sites and present great potentials as prognostic biomarkers for guiding individualized treatment in lung cancer. To date, various methods have been developed to capture CTCs in peripheral blood, and some approaches for the detection of CTC in lung cancer have shown both high sensitivity and specificity. The CTC analyses offer much promise as a real-time 'liquid biopsy' for prognosis evaluation and therapy intervention in lung cancer. In this Review, we present and discuss the current status of CTC detection and applications in lung cancer.
肺癌是癌症相关死亡的最常见原因，大多数患者死于远处转移。循环肿瘤细胞（CTC）是从原发性或转移性部位扩散到外周血中的癌细胞，作为肺癌个体化治疗指导的预后生物标志物具有巨大的潜力。迄今为止，已经开发出各种方法来捕获外周血中的 CTC，一些用于检测肺癌 CTC 的方法已经显示出较高的敏感性和特异性。CTC 分析有望成为一种实时的“液体活检”，用于评估肺癌的预后和治疗干预。在这篇综述中，我们介绍并讨论了 CTC 检测在肺癌中的现状和应用。
