Zhao Qingtao, Yuan Zheng, Wang Huien, Zhang Hua, Duan Guochen, Zhang Xiaopeng
Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, China.
Department of Thoracic Surgery, Children's Hospital of Hebei Province, Shijiazhuang, China.
J Int Med Res. 2021 Mar;49(3):300060521994926. doi: 10.1177/0300060521994926.
We systematically reviewed the literature relating to the diagnostic accuracy of circulating tumor cells (CTCs) for the clinical determination of lung cancer.
This meta-analysis aimed to evaluate the diagnostic accuracy of CTCs for the clinical determination of lung cancer. The PubMed, Embase, Cochrane Library, and Web of Science databases were searched for relevant studies up to 31 May 2020. The numbers of patients with true positive, false positive, false negative, and true negative results were extracted from each individual study. Pooled sensitivity, specificity, and area under the curve values were calculated with 95% confidence intervals (CI).
Twenty-one studies with 3997 subjects met the inclusion criteria. The overall diagnostic accuracy was assessed. The pooled sensitivity and specificity were 0.72 (95%CI: 0.65-0.79) and 0.96 (95%CI: 0.91-0.98), respectively, and the pooled positive and negative likelihood ratios were 16.86 (95%CI: 7.65-37.12) and 0.29 (95%CI: 0.23-0.37), respectively. The combined diagnostic odds ratio was 58.12 (95%CI: 24.82-136.09).
This meta-analysis indicated that CTCs had good diagnostic value for detecting lung cancer.
我们系统回顾了与循环肿瘤细胞（CTC）用于肺癌临床诊断准确性相关的文献。
本荟萃分析旨在评估CTC用于肺癌临床诊断的准确性。检索了截至2020年5月31日的PubMed、Embase、Cochrane图书馆和Web of Science数据库中的相关研究。从每项独立研究中提取真阳性、假阳性、假阴性和真阴性结果的患者数量。计算合并敏感性、特异性和曲线下面积值，并给出95%置信区间（CI）。
21项研究共3997名受试者符合纳入标准。评估了总体诊断准确性。合并敏感性和特异性分别为0.72（95%CI：0.65 - 0.79）和0.96（95%CI：0.91 - 0.98），合并阳性似然比和阴性似然比分别为16.86（95%CI：7.65 - 37.12）和0.29（95%CI：0.23 - 0.37）。合并诊断比值比为58.12（95%CI：24.82 - 136.09）。
本荟萃分析表明，CTC对肺癌检测具有良好的诊断价值。
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