Matsuda T, Okada K, Yoshida O
Department of Urology, Faculty of Medicine, Kyoto University.
Hinyokika Kiyo. 1988 Mar;34(3):569-73.
A multi-institutional clinical study was performed on the efficacy of Ofloxacin against chlamydial urethritis in males between January and June, 1987. Chlamydia trachomatis was detected in 68 (38.2%) among 178 patients with male urethritis by the antichlamydial FITC monoclonal antibody technic (Micro Trak). Neisseria gonorrhoeae was isolated in 51 patients (28.7%) and C. trachomatis was also detected in 8 of them. Ofloxacin was administered at a dosage of 600 mg divided into 3 doses for 14 days. One hundred and forty-eight patients including 53 with chlamydial urethritis were evaluable for clinical efficacy. C. trachomatis did not disappear in 6 patients (13.6%) and 2 (8.3%) after the therapy for 7 and 14 days, respectively. After 7 days of therapy, both the pathogen and urethral excretions had disappeared from 79.6% of the patients with chlamydial urethritis, and from 84.8% of those with gonorrheal urethritis; and after 14 days of therapy they had disappeared from 94.1 and 90.9% of the patients, respectively.
1987年1月至6月期间，针对氧氟沙星治疗男性衣原体性尿道炎的疗效进行了一项多机构临床研究。采用抗衣原体异硫氰酸荧光素单克隆抗体技术（Micro Trak），在178例男性尿道炎患者中检测到沙眼衣原体的有68例（38.2%）。分离出淋病奈瑟菌的有51例患者（28.7%），其中8例同时检测出沙眼衣原体。氧氟沙星给药剂量为600mg，分3次服用，疗程14天。包括53例衣原体性尿道炎患者在内的148例患者可评估临床疗效。治疗7天和14天后，分别有6例（13.6%）和2例（8.3%）患者的沙眼衣原体未消失。治疗7天后，衣原体性尿道炎患者中79.6%的患者病原体和尿道分泌物消失，淋病性尿道炎患者中84.8%的患者病原体和尿道分泌物消失；治疗14天后，这两类患者中病原体和尿道分泌物消失的比例分别为94.1%和90.9%。
