Asano H, Hibi H, Ohshima S, Kinukawa T, Matuura O, Takeuchi N, Hattori R, Hasegawa S, Fujita T, Matsui M
Department of Urology, Aichi Saisikai Hospital.
Hinyokika Kiyo. 1989 Jan;35(1):191-7.
Clinical effects of ofloxacin (OFLX) in the treatment of the patients with chlamydial urethritis was studied. OFLX was administered at a dose of 200 mg, three times daily (600 mg) for 14 days. In all of the 26 patients with chlamydial urethritis, C. trachomatis was eliminated in 7 to 14 days after the start of administration. The subjective clinical symptoms such as pain on urination and abnormal urethral feeling was disappeared in all cases within 7 days after the administration. The objective clinical symptoms, urethral discharge, polymorphonuclear leukocyte (PMNL) in urethral discharge and PMNL in first urine were improved in 94, 68, 91% respectively on 14 days after the administration. Overall clinical efficacy rate of OFLX on 7 days, 14 days and 21 days after the administration in this study was 63, 82, 91% respectively. Whereas subjective symptoms of side effects were noted in 2 patients (7.6%), any additional medical care was needed in none of them. Because of the marked improvement of clinical symptoms and the safety administration, OFLX could be the first regimen to be chosen for the treatment of the patients with chlamydial urethritis.
研究了氧氟沙星（OFLX）治疗衣原体尿道炎患者的临床效果。氧氟沙星给药剂量为200毫克，每日三次（600毫克），共14天。在所有26例衣原体尿道炎患者中，给药开始后7至14天沙眼衣原体被清除。所有病例在给药后7天内排尿疼痛和尿道异常感觉等主观临床症状均消失。给药14天后，客观临床症状、尿道分泌物、尿道分泌物中的多形核白细胞（PMNL）和首次尿液中的PMNL分别改善了94%、68%、91%。本研究中氧氟沙星给药后7天、14天和21天的总体临床有效率分别为63%、82%、91%。2例患者（7.6%）出现了副作用的主观症状，但均无需额外医疗护理。由于临床症状明显改善且给药安全，氧氟沙星可作为治疗衣原体尿道炎患者的首选方案。
