The Brain and Mind Institute and Department of Psychology, University of Western Ontario, London, Canada.
Department of Psychology, University of Toronto, Toronto, Canada.
Memory. 2021 Aug;29(7):884-894. doi: 10.1080/09658211.2019.1643891. Epub 2019 Jul 24.
Déjà vu is characterised by feelings of familiarity and concurrent awareness that this familiarity is wrong. Previous neuropsychological research has linked déjà vu during seizures in individuals with unilateral temporal-lobe epilepsy (uTLE) to rhinal-cortex abnormalities, and to recognition-memory deficits that selectively affect familiarity assessment. Here, we examined whether bilateral TLE patients with déjà vu (bTLE) show a similar pattern of performance. Using two experimental tasks, we found that bTLE patients exhibit deficits not only for familiarity but also for recollection. Relative to uTLE, this broader impairment also involved hippocampal abnormalities. Our findings confirm rhinal-cortex contributions to the generation of false familiarity in déjà vu that parallel its contributions to familiarity on recognition-memory tasks. While they do not rule out a role for recollection in identifying this familiarity as wrong, the deficits observed in bTLE patients weigh against the notion that any such role is necessary for déjà vu to occur.
记忆错觉的特征是一种熟悉的感觉，同时也意识到这种熟悉感是错误的。先前的神经心理学研究已经将单侧颞叶癫痫（uTLE）患者癫痫发作期间的记忆错觉与嗅球皮层异常联系起来，并与识别记忆缺陷联系起来，这些缺陷选择性地影响熟悉度评估。在这里，我们研究了是否存在记忆错觉的双侧颞叶癫痫（bTLE）患者表现出类似的表现模式。使用两项实验任务，我们发现 bTLE 患者不仅表现出熟悉度缺陷，而且还表现出回忆缺陷。与 uTLE 相比，这种更广泛的损伤还涉及海马体异常。我们的研究结果证实了嗅球皮层对记忆错觉中虚假熟悉感的产生的贡献，这与它对识别记忆任务中熟悉感的贡献是平行的。虽然它们不能排除在将这种熟悉感识别为错误时回忆的作用，但 bTLE 患者的缺陷与记忆错觉发生时任何此类作用都是必要的观点相矛盾。
