Neurologie, Hôpital Purpan, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Centre de Recherche Cerveau et Cognition, Université de Toulouse, Université Paul Sabatier Toulouse, Toulouse, France.
Memory. 2021 Aug;29(7):843-858. doi: 10.1080/09658211.2019.1673426. Epub 2019 Oct 6.
Several studies pertaining to déjà vu have consistently made a connection with the perirhinal region, a region located below the hippocampus. This idea is strengthened by the fact that déjà vu is an erroneous sense of familiarity and that familiarity appears to largely depend on the perirhinal region in healthy subjects. In this context, the role of the hippocampus is particularly unclear as it is unknown whether or not it plays a role in the genesis of déjà vu. We report on the case of OHVR, an epileptic patient who suffers from severe episodic amnesia related to massive isolated bilateral damage to the hippocampus. In contrast, the perirhinal region is intact structurally and functionally. This patient reports frequent déjà vu but also another experiential phenomenon with a prominent feeling of prescience, which shows some of the characteristics of déjà vécu. She clearly distinguishes both. She also developed a form of synaesthesia by attributing affective valence to numbers. This study shows that déjà vu can occur in cases of amnesia with massively damaged hippocampi and confirms that the perirhinal region is a core region for déjà vu, using a different approach from previous reports. It also provides clues about a potential influence of hippocampal alterations in déjà vécu.
几项与“既视感”相关的研究都与位于海马体下方的边缘系统后区（perirhinal region）有一致的联系。这个想法得到了既视感是一种错误的熟悉感的事实的支持，而且在健康受试者中，熟悉感似乎在很大程度上依赖于边缘系统后区。在这种情况下，海马体的作用尤其不清楚，因为尚不清楚它是否在既视感的产生中发挥作用。我们报告了 OHVR 的病例，这是一名患有严重阵发性健忘症的癫痫患者，其健忘症与双侧海马体严重孤立性损伤有关。相比之下，边缘系统后区在结构和功能上是完整的。该患者报告经常出现既视感，但也报告了另一种具有明显预知感的体验现象，这显示了一些既视感的特征。她清楚地区分了这两者。她还通过将情感价值归因于数字，发展出了一种联觉形式。这项研究表明，在海马体严重受损的健忘症病例中也会出现既视感，并且使用与以前报告不同的方法证实了边缘系统后区是既视感的核心区域。它还为海马体改变在既视感中的潜在影响提供了线索。
