低促性腺激素性性腺功能减退男性的睾丸促性腺激素受体

Testicular gonadotropin receptors in men with hypogonadotropic hypogonadism.

作者信息

Namiki M, Kitamura M, Nonomura N, Nakamura M, Okuyama A, Sonoda T, Matsumoto K

机构信息

Department of Urology and Pathology, Osaka University Medical School, Japan.

出版信息

Arch Androl. 1988;20(1):81-5. doi: 10.3109/01485018808987056.

DOI:10.3109/01485018808987056

PMID:3133996

Abstract

To investigate the reason(s) why human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG) treatment is not always effective for men with hypogonadotropic hypogonadism (HH), we measured hCG and follicle-stimulating hormone (FSH) receptors in testicular tissues obtained by biopsy from 5 men with idiopathic HH and 2 men with secondary HH. The difference between these 7 men and age-matched controls in the numbers of testicular hCG and FSH receptors were not significant. Histologic examination of the testes also showed that Leydig and Sertoli cells had a normal appearance. Therefore, responsiveness to gonadotropins seems to be preserved in the testes of men with HH. Fro these results it could be concluded that combined hCG and hMG treatment may be used with good results for the treatment of HH.

摘要

为了探究人绒毛膜促性腺激素（hCG）和人绝经期促性腺激素（hMG）治疗对低促性腺激素性性腺功能减退（HH）男性并非总是有效的原因，我们对5例特发性HH男性和2例继发性HH男性活检获取的睾丸组织中的hCG和促卵泡生成素（FSH）受体进行了检测。这7名男性与年龄匹配的对照组在睾丸hCG和FSH受体数量上的差异并不显著。睾丸的组织学检查也显示，睾丸间质细胞和支持细胞外观正常。因此，HH男性的睾丸似乎仍保留对促性腺激素的反应性。基于这些结果可以得出结论，hCG和hMG联合治疗可能对HH的治疗效果良好。