自闭症谱系障碍与产后因素：巴西的一项病例对照研究。
AUTISM SPECTRUM DISORDER AND POSTNATAL FACTORS: A CASE-CONTROL STUDY IN BRAZIL.
作者信息
Maia Fernanda Alves, Oliveira Liliane Marta Mendes, Almeida Maria Tereza Carvalho, Alves Maria Rachel, Saeger Vanessa Souza de Araújo, Silva Victor Bruno da, Oliveira Victória Spínola Duarte de, Martelli Junior Hercílio, Brito Maria Fernanda Santos Figueiredo, Silveira Marise Fagundes da
机构信息
Universidade Estadual de Montes Claros, Montes Claros, MG, Brazil.
出版信息
Rev Paul Pediatr. 2019 Jul 18;37(4):398-405. doi: 10.1590/1984-0462/;2019;37;4;00006. eCollection 2019.
OBJECTIVE
To estimate the magnitude of the association between Autism Spectrum Disorder (ASD) and postnatal factors in a Brazilian population.
METHODS
A case-control study was performed with 253 individuals diagnosed with ASD and 886 individuals without signs of the disorder. A semi-structured questionnaire and the multiple logistic regression model were adopted in the data analysis. To estimate the magnitude of associations, the crude and adjusted Odds Ratio (OR) was used.
RESULTS
An association with the following factors was found: having been born with congenital malformation (OR 4.24; confidence interval of 95% - 95%CI 1.92-9.34), neonatal jaundice (OR 1.43; 95%CI 1.01-2.02), absence of crying at birth and seizure episode in childhood (OR 5.75; 95%CI 3.37-9.81). The magnitude of the association was higher in the children/adolescents who had two or more postnatal complications (OR 6.39; 95%CI 4.10-10.00).
CONCLUSIONS
The findings of the present study suggest that malformation, neonatal jaundice, absence of crying at birth and seizure episodes in childhood are important factors to be considered when studying the etiology of ASD.
目的
评估巴西人群中自闭症谱系障碍（ASD）与产后因素之间关联的程度。
方法
开展了一项病例对照研究，研究对象为253名被诊断患有ASD的个体和886名无该疾病迹象的个体。数据分析采用半结构化问卷和多元逻辑回归模型。为评估关联程度，使用了粗比值比（OR）和调整后的比值比。
结果
发现与以下因素存在关联：先天性畸形出生（OR 4.24；95%置信区间 - 95%CI 1.92 - 9.34）、新生儿黄疸（OR 1.43；95%CI 1.01 - 2.02）、出生时不哭以及童年期癫痫发作（OR 5.75；95%CI 3.37 - 9.81）。在有两种或更多产后并发症的儿童/青少年中，关联程度更高（OR 6.39；95%CI 4.10 - 10.00）。
结论
本研究结果表明，畸形、新生儿黄疸、出生时不哭以及童年期癫痫发作是研究ASD病因时需要考虑的重要因素。
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