Kilian M, Sørensen I, Frederiksen W
J Clin Microbiol. 1979 Mar;9(3):409-12. doi: 10.1128/jcm.9.3.409-412.1979.
A total of 130 Haemophilus strains, comprising virtually all isolates from Danish and Norwegian cases of Haemophilus meningitis occurring in the period from October 1975 through September 1976, were examined by biochemical and serological means. All isolates were identified as H. influenzae and, except for one noncapsulated strain, possessed a capsule of serotype b. The vast majority of strains (93%) belonged to biotype I, which, in contrast to biotypes II and III, is rarely encountered as a commensal of the upper respiratory tract. This finding is a strong incentive for studies of possible additional virulence factors associated with biotype I organisms. The results are discussed in the light of North American reports, which have suggested changes in the etiology of Haemophilus meningitis.
对130株嗜血杆菌进行了生化和血清学检测,这些菌株几乎涵盖了1975年10月至1976年9月期间丹麦和挪威所有的嗜血杆菌性脑膜炎病例分离株。所有分离株均鉴定为流感嗜血杆菌,除1株无荚膜菌株外,其余均具有b型荚膜。绝大多数菌株(93%)属于生物I型,与生物II型和III型不同,生物I型在上呼吸道共生菌中很少见。这一发现有力地推动了对与生物I型菌株相关的其他可能毒力因子的研究。根据北美报告讨论了结果,这些报告表明嗜血杆菌性脑膜炎的病因有所变化。