Batista Tânia Filipa Pereira, Manuel Paula Ferreira, Correia António Carvalho
Internal Medicine, Hospital Center Tondela-Viseu - Avenida Rei D. Duarte, 3504-509, Viseu, Portugal.
Rev Assoc Med Bras (1992). 2019 Jul 22;65(6):772-774. doi: 10.1590/1806-9282.65.6.772.
The essential thrombocythemia is one of the seven described forms of myeloproliferative neoplasms. It is characterized by megakaryocytic hyperplasia with consequent thrombocytosis maintained in the peripheral blood, favoring the occurrence of thrombo-hemorrhagic phenomena. We present the case of an 81-year-old woman with a history of ischemic stroke in the context of a sustained thrombocytosis, which led to a spinal study and a search for the V617F mutation in the JAK2 gene, which was positive. The patient started cytoreductive therapy with hydroxyurea with favorable current evolution.
原发性血小板增多症是所描述的七种骨髓增殖性肿瘤之一。其特征是巨核细胞增生，继而外周血中出现血小板增多，易引发血栓-出血现象。我们报告一例81岁女性患者，有缺血性中风病史，存在持续性血小板增多，为此进行了脊髓检查并检测JAK2基因的V617F突变，结果呈阳性。患者开始使用羟基脲进行细胞减灭治疗，目前病情进展良好。
